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Temsavir

Temsavir Structure
Temsavir structure
CAS No.
701213-36-7
Chemical Name:
Temsavir
Synonyms
CS-1668;Temsavir;EOS-62215;BMS-626529;BMS 626529;BMS-626529, Temsavir;BMS 626529; BMS626529;Temsavir (BMS-626529);Foscarbidopa Impurity 13;(1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.02,6]UNDECAN-3-OL
CBNumber:
CB12645134
Molecular Formula:
C24H23N7O4
Molecular Weight:
473.48
MDL Number:
MFCD22665723
MOL File:
701213-36-7.mol
Last updated:2024-11-19 23:02:33
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Temsavir Properties

Melting point 263-265°C
Boiling point 787.6±70.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 10.92±0.40(Predicted)
color Off-White to Pale Beige
InChI InChI=1S/C24H23N7O4/c1-15-27-14-31(28-15)22-20-19(18(35-2)13-26-22)17(12-25-20)21(32)24(34)30-10-8-29(9-11-30)23(33)16-6-4-3-5-7-16/h3-7,12-14,25H,8-11H2,1-2H3
InChIKey QRPZBKAMSFHVRW-UHFFFAOYSA-N
SMILES C(N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C(C1C2C(OC)=CN=C(N3C=NC(C)=N3)C=2NC=1)=O
FDA UNII 4B6J53W8N3

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

Temsavir price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18413 BMS 626529 ≥98% 701213-36-7 1mg $44 2024-03-01 Buy
Cayman Chemical 18413 BMS 626529 ≥98% 701213-36-7 5mg $172 2024-03-01 Buy
Cayman Chemical 18413 BMS 626529 ≥98% 701213-36-7 10mg $299 2024-03-01 Buy
Cayman Chemical 18413 BMS 626529 ≥98% 701213-36-7 50mg $849 2024-03-01 Buy
TRC T017900 Temsavir 701213-36-7 50mg $65 2021-12-16 Buy
Product number Packaging Price Buy
18413 1mg $44 Buy
18413 5mg $172 Buy
18413 10mg $299 Buy
18413 50mg $849 Buy
T017900 50mg $65 Buy

Temsavir Chemical Properties,Uses,Production

Description

BMS 626529 is an inhibitor of HIV-1 attachment. It binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry. BMS 626529 reduces infectivity of laboratory strains and clinical isolates of HIV-1 (EC50s = 0.4-2,000 and 25-2,000 nM, respectively) with cytotoxic concentration (CC50) values greater than 100 μM in a panel of mammalian cell lines.

Uses

Temsavir is a Fostemsavir (CAS# 864953-29-7) intermediate and an antiviral agent. It is an HIV-1 attachment inhibitor.

Uses

Temsavir is an FDA-approved HIV-1 adhesion inhibitor. It blocks the interaction of Env with CD4. This molecule also stabilises Env in a pre-fused 'closed' conformation, which is the preferred target of several broad-spectrum neutralising antibodies (bNAbs). temsavir treatment also reduces the ability of bNAbs to eliminate HIV-1 infected cells through antibody-dependent cellular cytotoxicity (ADCC). fostemsavir, a pre-drug of temsavir, was approved in the FDA on 2 July 2020 approved for the treatment of patients with multidrug-resistant HIV-1 infection.

brand name

BMS-626529

Biological Functions

Temsavir prevents the host cell receptor CD4 from interacting with Env by binding to the pocket under the gp120 β20-β21 ring of the Env subunit. It prevents viral entry and also stabilises Env in a 'closed' conformation[3].

in vitro

the activity of bms-626529 is virus dependent, due to heterogeneity within gp120. bms-626529 had half-maximal effective concentration values of6 log10, with half-maximal effective concentration values in the low pm range against the most susceptible viruses. measurement of the binding affinity of bms-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life [1].

target

HIV-1 subtype A envelope

References

[1] nowicka-sans b, gong yf, mcauliffe b, dicker i, ho ht, zhou n, eggers b, lin pf, ray n, wind-rotolo m, zhu l, majumdar a, stock d, lataillade m, hanna gj, matiskella jd, ueda y, wang t, kadow jf, meanwell na, krystal m.  in vitro antiviral characteristics of hiv-1 attachment inhibitor bms-626529, the active component of the prodrug bms-663068. antimicrob agents chemother. 2012;56(7):3498-507.
[2] nettles re, schürmann d, zhu l, stonier m, huang sp, chang i, chien c, krystal m, wind-rotolo m, ray n, hanna gj, bertz r, grasela d.  pharmacodynamics, safety, and pharmacokinetics of bms-663068, an oral hiv-1 attachment inhibitor in hiv-1-infected subjects. j infect dis. 2012;206(7):1002-11.
[3] MARIANNE BOUTIN. Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage.[J]. Viruses-Basel, 2023. DOI:10.3390/v15051189.

Temsavir Preparation Products And Raw materials

Raw materials

Preparation Products

Temsavir Suppliers

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5221 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29882 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8838 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078 info@rochipharma.com China 431 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15353 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Supplier Advantage
Wuhan Jingkang en Biomedical Technology Co., Ltd
58
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		58
AFINE CHEMICALS LIMITED 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from Temsavir manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Temsavir pictures 2024-11-19 Temsavir
701213-36-7
 US $58.00-178.00 / mg 98.06% 10g TargetMol Chemicals Inc.
BMS 626529 pictures 2019-07-10 BMS 626529
701213-36-7
 US $1.00 / KG 1KG 98% 150KG Career Henan Chemical Co
  • Temsavir pictures
  • Temsavir
    701213-36-7
  • US $58.00-178.00 / mg
  • 98.06%
  • TargetMol Chemicals Inc.
  • BMS 626529 pictures
  • BMS 626529
    701213-36-7
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

Temsavir Spectrum

BMS 626529(701213-36-7)1HNMR
1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]piperazine BMS626529 BMS 626529 BMS-626529 1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]piperazine Temsavir 1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.02,6]UNDECAN-3-OL 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]- EOS-62215 Temsavir (BMS-626529) BMS 626529; BMS626529 BMS-626529, Temsavir CS-1668 1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione Foscarbidopa Impurity 13 701213-36-7 C24H23N7O4