(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
- CAS No.
- 915095-86-2
- Chemical Name:
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
- Synonyms
- Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
- CBNumber:
- CB12651407
- Molecular Formula:
- C13H7ClFIO
- Molecular Weight:
- 360.55
- MDL Number:
- MFCD22665920
- MOL File:
- 915095-86-2.mol
- MSDS File:
- SDS
Melting point | 64-70oC |
---|---|
Boiling point | 415℃ |
Density | 1.752 |
Flash point | 205℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | Chloroform (Slightly), Ethyl Acetate |
form | Solid |
color | Off-White |
InChI | InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H |
InChIKey | KNYGUQLVFSPVRI-UHFFFAOYSA-N |
SMILES | C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Safety Statements | 24/25 |
HS Code | 29142990 |
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C368575 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone | 915095-86-2 | 2.5g | $595 | 2021-12-16 | Buy |
AK Scientific | 9597AF | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone | 915095-86-2 | 100g | $605 | 2021-12-16 | Buy |
Apolloscientific | PC540099 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 98% | 915095-86-2 | 100g | $634 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 91537 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone | 915095-86-2 | 1g | $725 | 2021-12-16 | Buy |
Apolloscientific | PC540099 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 98% | 915095-86-2 | 25g | $224 | 2021-12-16 | Buy |
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemical Properties,Uses,Production
Uses
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.
Synthesis
5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Ensky Pharmaceutical Co.,Ltd. | +86-23-86815286 +86-13983794297 | sales@ensky-chemical.com | China | 91 | 58 |
Suzhou Nordica Biopharma CO.,LTD | +8618136148818 | anna.ran@nordicabio.com | China | 298 | 58 |
Cangzhou Kangrui Pharma Tech Co. Ltd., | +8618632776803 | cangzhoukangrui@126.com | China | 733 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 255 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Shandonghaohong biotechnology Co.,ltd. | 0635-6175299 13961496334 | sale@inyelchem.com | CHINA | 44 | 55 |
View Lastest Price from (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-24 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
|
US $0.00 / kg | 1kg | 98% | 500k | Shanghai Joiny Pharmaceutical Co.,LTD | ||
2024-08-15 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | ||
2024-03-28 | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
945065-86-2
|
US $0.00 / kg | 25kg | 98%-99% | Inquiry | PNP Biotech Co. Ltd |
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
945065-86-2
- US $0.00 / kg
- 98%-99%
- PNP Biotech Co. Ltd
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