Adelmidrol
- CAS No.
- 1675-66-7
- Chemical Name:
- Adelmidrol
- Synonyms
- Demiqu;NSC 27132;Adelmidrol;AdelMitrol;AdelMitrol USP/EP/BP;N,N'-Bis(2-hydroxyethyl)nonanediamide;N1,N9-bis(2-hydroxyethyl)-nonanediamide;Nonanediamide, N1,N9-bis(2-hydroxyethyl)-;China biggest manufacturer,AdelMitrol,1675-66-7;NF-κB,Nuclear factor-kappaB,PPAR,COX,Adelmidrol,Cyclooxygenase,Peroxisome proliferator-activated receptors,inhibit,Inhibitor,Nuclear factor-κB
- CBNumber:
- CB12657232
- Molecular Formula:
- C13H26N2O4
- Molecular Weight:
- 274.36
- MDL Number:
- MFCD00868853
- MOL File:
- 1675-66-7.mol
- MSDS File:
- SDS
| Melting point | 132-134℃ |
|---|---|
| Boiling point | 596.4±45.0 °C(Predicted) |
| Density | 1.097±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMSO:77.5(Max Conc. mg/mL);282.47(Max Conc. mM) Ethanol:28.0(Max Conc. mg/mL);102.06(Max Conc. mM) Water:55.0(Max Conc. mg/mL);200.47(Max Conc. mM) |
| pka | 14.19±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19) |
| InChIKey | PAHZPHDAJQIETD-UHFFFAOYSA-N |
| SMILES | C(NCCO)(=O)CCCCCCCC(NCCO)=O |
| FDA UNII | 1BUC3685QU |
Adelmidrol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A247540 | Adelmidrol | 1675-66-7 | 25mg | $65 | 2021-12-16 | Buy |
| ChemScene | CS-4543 | Adelmidrol ≥98.0% | 1675-66-7 | 100mg | $72 | 2021-12-16 | Buy |
| AK Scientific | 1760CB | Adelmidrol | 1675-66-7 | 1g | $848 | 2021-12-16 | Buy |
| DC Chemicals | DC10745 | Adelmidrol >98% | 1675-66-7 | 1g | $800 | 2021-12-16 | Buy |
| Ambeed | A103800 | Adelmidrol 98+% | 1675-66-7 | 25mg | $24 | 2021-12-16 | Buy |
Adelmidrol Chemical Properties,Uses,Production
Description
N,N'-Bis(2-hydroxyethyl)nonanediamide, also named Admidol, is an anti-inflammatory ethanolamide derivative. It is hydrophilic and hydrophobic, favoring its solubility in water and organic media. As an naturally occurring saturated dicarboxylic acid, it is found in trace amounts in the human body and in some whole grains. Adelmidrol is an analogue of palmitoylethanolamide (PEA), which is a well-known anti-inflammatory and anti-oxidant compound. Adelmidrol was able to manage the significant incapacity of antioxidants and elevation of the oxidant burden[1-2].
Uses
Adelmidrol is an anti-inflammatory. It can be used in biological study of protective effect of adelmidrol as new palmitoylethanolamide analog for pharmacol. treatment of inflammatory bowel disease in mouse model.
Biological Activity
Adelmidrol is an analog of hexadecylamide ethanol (PEA) with anti-inflammatory activity.
in vitro
Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon.
p>
target
| NF-κB < span> | COX-2
| PPARγ
|
References
[1] Cordaro M, et al. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. BIOCHEMICAL PHARMACOLOGY, 2016; 90: 549-561
[2] Fusco R, et al. Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis. Antioxidants, 2020; 9.
[3] Guida F, et al. Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol. 2022; 12.
Adelmidrol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49978 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9026 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| Univar Solutions(China) Co., Ltd. | +8615902132654 | ivy.zhuang@univarsolutions.com | China | 654 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
View Lastest Price from Adelmidrol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Adelmidrol
1675-66-7
|
US $57.00-39.00 / mg | 99.35% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-05-11 | Adelmitrol
1675-66-7
|
US $10.00 / kg | 0.1kg | 0.98 | 1000kg | Gihi Chemicals Co., Limited | |
 |
2021-08-17 | AdelMitrol USP/EP/BP
1675-66-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Adelmidrol
1675-66-7
- US $57.00-39.00 / mg
- 99.35%
- TargetMol Chemicals Inc.
-
- Adelmitrol
1675-66-7
- US $10.00 / kg
- 0.98
- Gihi Chemicals Co., Limited
-
- AdelMitrol USP/EP/BP
1675-66-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited