Birinapant
- CAS No.
- 1260251-31-7
- Chemical Name:
- Birinapant
- Synonyms
- CS-801;TL 32711;Birinapan;Birinapant;SMAC mimetic;TL-32711 ≥98%;Birinapant, >=98%;Birinapant (TL32711);TL 32711. Birinapant;Birinapant USP/EP/BP
- CBNumber:
- CB12658183
- Molecular Formula:
- C42H56F2N8O6
- Molecular Weight:
- 806.94
- MDL Number:
- MFCD25976869
- MOL File:
- 1260251-31-7.mol
Melting point | >245oC (dec.) |
---|---|
Boiling point | 1090.5±65.0 °C(Predicted) |
Density | 1.320±0.06(20.0000℃) |
storage temp. | -20°C Freezer |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 13.99±0.46(Predicted) |
form | Solid |
color | White to Off-White |
FDA UNII | 6O4Z07B57R |
NCI Drug Dictionary | birinapant |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P280-P305+P351+P338 |
HS Code | 29339900 |
Birinapant price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19699 | Birinapant ≥95% | 1260251-31-7 | 1mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 19699 | Birinapant ≥95% | 1260251-31-7 | 5mg | $193 | 2024-03-01 | Buy |
Cayman Chemical | 19699 | Birinapant ≥95% | 1260251-31-7 | 10mg | $330 | 2024-03-01 | Buy |
Cayman Chemical | 19699 | Birinapant ≥95% | 1260251-31-7 | 25mg | $616 | 2024-03-01 | Buy |
TRC | B399730 | Birinapant | 1260251-31-7 | 5mg | $140 | 2021-12-16 | Buy |
Birinapant Chemical Properties,Uses,Production
Description
Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells. It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.
Uses
Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.
Definition
ChEBI: Birinapant is a dipeptide.
Enzyme inhibitor
This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors
target
XIAP
Birinapant Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23699 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15392 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
View Lastest Price from Birinapant manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-02 | Birinapant
1260251-31-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Birinapant
1260251-31-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd