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STF 31

STF 31 Structure
STF 31 structure
CAS No.
724741-75-7
Chemical Name:
STF 31
Synonyms
STF 31;CS-1575;STF31;STF 31;N'-(4-METHYLPHENYL)-4-PYRIDINECARBOXIMIDAMIDE;4-((4-(tert-Butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide; 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide;4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide;Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-;VHL,inhibitor,RCC4/VHL,STF31,Autophagy,STF 31,STF-31,GLUT,Glucose transporter,GLUT1,inhibit,glucose,RCC4
CBNumber:
CB12663075
Molecular Formula:
C23H25N3O3S
Molecular Weight:
423.53
MDL Number:
MFCD04153828
MOL File:
724741-75-7.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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STF 31 Properties

Density 1.247±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble20mg/mL, clear
pka 11.28±0.50(Predicted)
form powder
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  46
WGK Germany  3
NFPA 704
0
2 0

STF 31 price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1108 STF-31 ≥98% (HPLC) 724741-75-7 5mg $149 2024-03-01 Buy
Sigma-Aldrich SML1108 STF-31 ≥98% (HPLC) 724741-75-7 25mg $594 2024-03-01 Buy
Cayman Chemical 11173 STF-31 ≥98% 724741-75-7 1mg $44 2024-03-01 Buy
Cayman Chemical 11173 STF-31 ≥98% 724741-75-7 5mg $118 2024-03-01 Buy
Cayman Chemical 11173 STF-31 ≥98% 724741-75-7 10mg $214 2024-03-01 Buy
Product number Packaging Price Buy
SML1108 5mg $149 Buy
SML1108 25mg $594 Buy
11173 1mg $44 Buy
11173 5mg $118 Buy
11173 10mg $214 Buy

STF 31 Chemical Properties,Uses,Production

Description

Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC50 = ~1 μM) that blocks glucose uptake. It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1. Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression. STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.

Uses

STF 31 is used in biological studies as pyridylanilinothiazoles and pyridylphenylsulfonyl benzamides scaffolds use to prepare affinity chromatoraphy reagents for cancer targeting. STF 31 is an inhibitor of GLUT1 which blocks glucose uptake.

Biochem/physiol Actions

STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.

storage

Store at RT

References

1) Chan?et al. (2011),?Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality; Sci. Transl. Med.,?3?94ra70 2) Adams?et al., (2014),?NAMPT is the Cellular Target of STF-31-Like Small-Molecule Probes; ACS Chem. Biol.,?9?2447 3) Dragovich?et al. (2014),?Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT); Bioorg. Med. Chem. Lett.,?24?954 4)Kraus?et al.?(2018),?Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell Oncol.(Dordr)?41?485

STF 31 Preparation Products And Raw materials

Raw materials

Preparation Products

STF 31 Suppliers

Global( 107)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from STF 31 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
STF-31 pictures 2024-11-19 STF-31
724741-75-7
 US $32.00-74.00 / mg 99.98% 10g TargetMol Chemicals Inc.
4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide pictures 2019-12-31 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide
724741-75-7
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • STF-31 pictures
  • STF-31
    724741-75-7
  • US $32.00-74.00 / mg
  • 99.98%
  • TargetMol Chemicals Inc.

STF 31 Spectrum

STF 31(724741-75-7)1HNMR

724741-75-7(STF 31)Related Search:

Geldanamycin TCPOBOP Adapalene AAL-993
STF 31 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide N'-(4-METHYLPHENYL)-4-PYRIDINECARBOXIMIDAMIDE 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide STF31;STF 31 CS-1575 Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl- 4-((4-(tert-Butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide VHL,inhibitor,RCC4/VHL,STF31,Autophagy,STF 31,STF-31,GLUT,Glucose transporter,GLUT1,inhibit,glucose,RCC4 724741-75-7 72474-75-7 Inhibitors API