ChemicalBook >> CAS DataBase List >>CC 930
CC 930
- CAS No.
- 899805-25-5
- Chemical Name:
- CC 930
- Synonyms
- CC930;MCC930;CC 930;CC-930;CS-1152;Tanziser;Tanzisertib;CC-930(Tanzisertib);TANZISERTIB (CC-930);TANZISERTIB; CC930; CC 930
- CBNumber:
- CB12666607
- Molecular Formula:
- C21H23F3N6O2
- Molecular Weight:
- 448.44
- MDL Number:
- MFCD23160040
- MOL File:
- 899805-25-5.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:00
| Boiling point | 626.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 15.05±0.40(Predicted) |
| color | Off-white to yellow |
| FDA UNII | M5O06306UO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
CC 930 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22466 | CC-930 ≥98% | 899805-25-5 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 22466 | CC-930 ≥98% | 899805-25-5 | 5mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 22466 | CC-930 ≥98% | 899805-25-5 | 10mg | $274 | 2024-03-01 | Buy |
| Cayman Chemical | 22466 | CC-930 ≥98% | 899805-25-5 | 25mg | $595 | 2024-03-01 | Buy |
| TRC | T007100 | Tanzisertib | 899805-25-5 | 5mg | $150 | 2021-12-16 | Buy |
CC 930 Chemical Properties,Uses,Production
Uses
Tanzisertib is a potent, selective, and orally active c-Jun amino-terminal kinase (JNK) inhibitor used for treatment of dermal fibrosis.
Biological Activity
Tanzisertib (CC-930, JNK-930, JNKI-1) has an ATP-competitive inhibitory effect on the phosphorylation of the JNK-dependent protein substrate c-Jun and all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM), selective inhibition of ERK1 and p38a with IC50 of 0.48 μM and 3.4 μM, respectively .
in vivo
In the acute PK-PD rat model of LPS-induced TNFα production, oral administration of 10 mg/kg and 30 mg/kg of CC-930 reduced the production of TNFα in vivo by 23% and 77%, respectively. CC-930 is well tolerated in vivo and its effect is proportional to dose.
target
| Target | Value |
| JNK3 (Cell-free assay) | 0.006 μM |
| JNK2 (Cell-free assay) | 0.007 μM |
| 0.061 μM |
CC 930 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 83)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35425 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
CC930
CC-930
Tanzisertib
trans-4-[[9-[(3S)-Tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]cyclohexanol
4-[[9-[(3s)-oxolan-3-yl]-8-(2,4,6-trifluoroanilino)purin-2-yl]amino]cyclohexan-1-ol
CC 930
MCC930
TANZISERTIB (CC-930)
Tanzisertib(CC-930) (free base)
TANZISERTIB; CC930; CC 930
CC-930(Tanzisertib)
CS-1152
Cyclohexanol, 4-[[9-[(3S)-tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]-, trans-
trans-4-((9-((S)-tetrahydrofuran-3-yl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)cyclohexanol
Tanzisertib,Inhibitor,inhibit,CC 930,CC930,JNK
Tanziser
899805-25-5
C21H23F3N6O2
MAPK