P-Selectin Inhibitor
- CAS No.
- 851546-61-7
- Chemical Name:
- P-Selectin Inhibitor
- Synonyms
- PSI-697;PSI 697,PSI697;P-Selectin Inhibitor;PSI-697(P-Selectin Inhibitor);Benzo[h]quinoline-4-carboxylic acid, 2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydro-3-hydroxy-
- CBNumber:
- CB12667679
- Molecular Formula:
- C21H18ClNO3
- Molecular Weight:
- 367.83
- MDL Number:
- MFCD09832577
- MOL File:
- 851546-61-7.mol
- MSDS File:
- SDS
| Boiling point | 553.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.383±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 45.8 mg/mL (124.51 mM) |
| pka | 0.89±0.20(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | LH1XC916ME |
P-Selectin Inhibitor Chemical Properties,Uses,Production
Uses
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].
in vivo
PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].
PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].
| Animal Model: | 4-5 weeks male Sprague-Dawley rat (50-100 g)[1] |
| Dosage: | 0 mg/kg, 30 mg/kg, 50 mg/kg |
| Administration: | Oral administration |
| Result: | At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control. |
References
[1] Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther. DOI:10.1124/jpet.107.128124
[2] Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97(3):400-7. PMID:17334507
[3] Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44(3):625-32. DOI:10.1016/j.jvs.2006.05.021
P-Selectin Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
P-Selectin Inhibitor Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2953 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9772 | 58 |
| Absin Bioscience Inc. | 021-38015121 18438616290 | wulan@absin.cn | China | 24731 | 58 |
