Deltarasin (hydrochloride)
- CAS No.
- 1440898-82-7
- Chemical Name:
- Deltarasin (hydrochloride)
- Synonyms
- Deltarasin (hydrochloride);Deltarasin trihydrochloride;Deltarasin hydrochloride (1:?);2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
- CBNumber:
- CB12677061
- Molecular Formula:
- C40H40Cl3N5O
- Molecular Weight:
- 713.1375
- MDL Number:
- MFCD28252145
- MOL File:
- 1440898-82-7.mol
Deltarasin (hydrochloride) price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9001536 | Deltarasin (hydrochloride) ≥98% | 1440898-82-7 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 9001536 | Deltarasin (hydrochloride) ≥98% | 1440898-82-7 | 5mg | $200 | 2024-03-01 | Buy |
| Cayman Chemical | 9001536 | Deltarasin (hydrochloride) ≥98% | 1440898-82-7 | 10mg | $276 | 2024-03-01 | Buy |
| TRC | D231318 | DeltarasinTrihydrochloride | 1440898-82-7 | 10mg | $250 | 2021-12-16 | Buy |
| ApexBio Technology | B1261 | Deltarasinhydrochloride | 1440898-82-7 | 5mg | $264 | 2021-12-16 | Buy |
Deltarasin (hydrochloride) Chemical Properties,Uses,Production
Uses
Deltarasin (cas# 1440898-82-7) is a useful research chemical.Deltarasin was used as a reagent in studying small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.
Biological Activity
deltarasin hydrochloride is a selective inhibitor of kras-pdeδ interaction with ic50 value of 41±12 nm [1].kras, also known as v-ki-ras2 kirsten rat sarcoma viral oncogene homolog, is a protein and works as a molecular on/off switch whose mutant is an essential step in the development of many cancers. pdeδ (prenyl binding protein) controls the spatial organization of k-ras, which enhances ras diffusion in the cytosol. inhibition of the ras-pdeδ interaction by small molecules impairs ras localization and signaling has becoming a promising strategy to treat cancers in clinic [1, 2].deltarasin hydrochloride is a potent kras-pdeδ interaction inhibitor. when tested with human pancreatic ductal adenocarcinoma cells deltarasin hydrochloride showed inhibition on kras-pdeδ interaction to inhibit oncogenic ras signaling and suppressed cell proliferation by binding to pdeδ with kd value of 41 nm [1].in nude mice model with panc-tu-i xenograft, administration of deltarasin hydrochloride (10, 15 mg/kg) impaired cells growth and decreased tumor volume after 9 days in a dose-dependent manner [1].
storage
Store at -20°C
References
[1]. zimmermann, g., et al., small molecule inhibition of the kras-pdedelta interaction impairs oncogenic kras signalling. nature, 2013. 497(7451): p. 638-42.
[2]. the kras-pdedelta interaction is a therapeutic target. cancer discov, 2013. 3(7): p. of20.
Deltarasin (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Deltarasin (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |