CK-636
- CAS No.
- 442632-72-6
- Chemical Name:
- CK-636
- Synonyms
- CK-636;CS-1421;CK-0944636;CK-636, >=98%;CK-636 USP/EP/BP;CK-636(CK-0944636;CK-636;CK636; CK 636;CK-636, 10 mM in DMSO;CK-636,CK-0944636, >98%;CK636; CK 636; CK-0944636; CK0944636; CK 0944636
- CBNumber:
- CB12685323
- Molecular Formula:
- C16H16N2OS
- Molecular Weight:
- 284.38
- MDL Number:
- MFCD03036245
- MOL File:
- 442632-72-6.mol
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
|---|---|
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | peach to light tan |
| InChIKey | ACAKNPKRLPMONU-UHFFFAOYSA-N |
| CAS DataBase Reference | 442632-72-6 |
| FDA UNII | 82XC8RSD8V |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
CK-636 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7374 | CK-636 ≥98% (HPLC) | 442632-72-6 | 5mg | $106 | 2024-03-01 | Buy |
| Sigma-Aldrich | C7374 | CK-636 ≥98% (HPLC) | 442632-72-6 | 25mg | $397 | 2023-01-07 | Buy |
| Cayman Chemical | 16243 | CK-636 ≥98% | 442632-72-6 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16243 | CK-636 ≥98% | 442632-72-6 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 16243 | CK-636 ≥98% | 442632-72-6 | 25mg | $270 | 2024-03-01 | Buy |
CK-636 Chemical Properties,Uses,Production
Description
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
In vitro
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
Uses
CK-636 is a small molecule that inhibits Actin-related protein 2/3 (Arp2/3) (1). Arp2/3 is a 7 subunits protein complex that regulates actin cytoskeleton (2). CK-636 interacts with Arp2/3 and prevents actin polymerization.
Biological Activity
CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.
CK-636 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22855 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| China Langchem Inc. | 0086-21-58956006 | China | 7811 | 57 |
