LDC000067
- CAS No.
- 1073485-20-7
- Chemical Name:
- LDC000067
- Synonyms
- LDC067;CS-1535;LDC-067;LDC 067;LDC000067;LDC000067(LDC-067);LDC000067 USP/EP/BP;LDC067;LDC 000067;LDC-000067;LDC 067;LDC-067;(3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide;3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide
- CBNumber:
- CB12716267
- Molecular Formula:
- C18H18N4O3S
- Molecular Weight:
- 370.43
- MDL Number:
- MFCD28137788
- MOL File:
- 1073485-20-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
LDC000067 price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 29419 | LDC000067 | 1073485-20-7 | 5mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 29419 | LDC000067 | 1073485-20-7 | 25mg | $317 | 2024-03-01 | Buy |
Cayman Chemical | 29419 | LDC000067 | 1073485-20-7 | 10mg | $143 | 2024-03-01 | Buy |
Tocris | 6752 | LDC000067 ≥98%(HPLC) | 1073485-20-7 | 25 | $316 | 2021-12-16 | Buy |
AK Scientific | 2509AH | (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane | 1073485-20-7 | 10mg | $177 | 2021-12-16 | Buy |
LDC000067 Chemical Properties,Uses,Production
Biological Activity
ldc000067 (ldc067) is a novel specific inhibitor of cdk9 with ic50 value of 44 ± 10 nm [1].cyclin-dependent kinase 9 (cdk9) is a cyclin-dependent kinase. cdk9 and cyclin t form the positive transcription elongation factor b (p-tefb) complex for rna polymerase ii and functions by phosphorylating the c-terminal domain of the largest subunit of rna polymerase ii [1].ldc000067 (ldc067) is a novel and highly specific cdk9 inhibitor. ldc000067 exhibited selectivity for cdk9 over other cdks in the range of 55-fold (vs. cdk2) to over 230-fold (vs. cdk6 and cdk7). ldc067 also inhibited transcription in a dose-dependent and atp-competitive manner. in whole cells, ldc000067 induced the tumor suppressor protein p53 activation and apoptosis. ldc000067 also selectively reduced short-lived mrnas, including those that encode regulators of apoptosis and proliferation such as myc and mcl1 [1].
in vitro
LDC000067 reduces Ser2-P in mESCs, induces p53 activation, and leads to apoptosis. In addition, LDC067 also dose-dependently inhibited the de novo RNA synthesis of P-TEFb-dependent cellular genes.
target
Target | Value |
CDK9 (Cell-free assay) | 44 nM |
CDK2 (Cell-free assay) | 2.441 μM |
storage
Store at -20°C
References
[1]. albert tk, rigault c, eickhoff j, et al. characterization of molecular and cellular functions of the cyclin-dependent kinase cdk9 using a novel specific inhibitor. br j pharmacol, 2014, 171(1): 55-68.
![344750-15-8](/StructureFile/ChemBookStructure9/GIF/CB2300940.gif)
![75634-03-6](/StructureFile/ChemBookStructure23/GIF/CB01078800.gif)
![1073485-20-7](/CAS/GIF/1073485-20-7.gif)
LDC000067 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
Chemia Biotechnology(Shanghai) Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from LDC000067 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2020-01-02 | (3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide
1073485-20-7
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- (3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide
1073485-20-7
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co