ChemicalBook >> CAS DataBase List >>RKS-262
RKS-262
- CAS No.
- 1041469-97-9
- Chemical Name:
- RKS-262
- Synonyms
- RKS-262;2H-1-Benzopyran-2-one, 6-bromo-4-chloro-3-[[(3-methyl-1,1-dioxido-4-thiomorpholinyl)imino]methyl]-
- CBNumber:
- CB12731132
- Molecular Formula:
- C15H14BrClN2O4S
- Molecular Weight:
- 433.7
- MDL Number:
- MOL File:
- 1041469-97-9.mol
Last updated:2023-03-31 09:12:58
RKS-262 Chemical Properties,Uses,Production
Description
RKS262 is a specific cycliCDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50):?~?10 nM) while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant (GI(50)?>?1?μM) to RKS262 treatment.
RKS-262 Preparation Products And Raw materials
Raw materials
Preparation Products
RKS-262 Suppliers
Global( 1)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
RKS-262
2H-1-Benzopyran-2-one, 6-bromo-4-chloro-3-[[(3-methyl-1,1-dioxido-4-thiomorpholinyl)imino]methyl]-
1041469-97-9