ChemicalBook >> CAS DataBase List >>AZ-5104

AZ-5104

AZ-5104 structure

CAS No.: 1421373-98-9

Chemical Name:: AZ-5104

Synonyms: AZ5104;AZ7550;AZD5104;AZ-5104;CS-1709;AZ-5104;AZ 5104;AZ5104; AZ-5104;Demethylated AZ9291;metabolite of AZD9291;Osimertinib Impurity A

CBNumber:: CB12741564

Molecular Formula:: C27H31N7O2

Molecular Weight:: 485.58

MDL Number:: MFCD28899992

MOL File:: 1421373-98-9.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

Request For Quotation

AZ-5104 Properties

Melting point	158 - 160°C
Density	1.267±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.68±0.70(Predicted)
form	Solid
color	Off-White
FDA UNII	2DWZ6SE1E1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

NFPA 704

	0
2		0

AZ-5104 price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17994	AZ 5104 ≥98%	1421373-98-9	5mg	$62	2024-03-01	Buy
Cayman Chemical	17994	AZ 5104 ≥98%	1421373-98-9	10mg	$115	2024-03-01	Buy
Cayman Chemical	17994	AZ 5104 ≥98%	1421373-98-9	25mg	$270	2024-03-01	Buy
Cayman Chemical	17994	AZ 5104 ≥98%	1421373-98-9	50mg	$477	2024-03-01	Buy
TRC	A795170	AZ5104	1421373-98-9	1mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
17994	5mg	$62	Buy
17994	10mg	$115	Buy
17994	25mg	$270	Buy
17994	50mg	$477	Buy
A795170	1mg	$55	Buy

AZ-5104 Chemical Properties,Uses,Production

Uses

AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).

Biological Activity

az5104, is the demethylated metabolite of azd-9291,is a potent egfr inhibitor. ic50 <1 nm, 6 nm, 1 nm, 25 nm, for egfr (l858r/t790m), egfr (l858r), egfr (l861q), and egfr (wildtype), respectively.egfr (epidermal growth factor receptor) is a receptor tyrosine kinase on the cell surface. the receptor activation leads to dimerization and tyrosine autophosphorylation. it induces downstream cellular responses such as modification in gene expression, cell proliferation and cytoskeletal rearrangement etc.compare to azd9291, az5104 has somewhat more potency in mutant egfr cell lines ex19del (2 nmol/l in pc-9), t790m (2 nmol/l in h1975), and wild-type egfr (33 nmol/l in lovo) cell lines. in a phenotypic assay, az5104 showed a greater potency across cell lines in a phenotypic assay.3 hours after oral dosing in the mouse, the circulating active metabolites in plasma is 33% for az5104. in both c/l858r and c/l+t mice, 5 mg/kg/day dose of az5104, also show efficacy in shrinking tumors.

References

1. cross da, ashton se, ghiorghiu s et al. azd9291, an irreversible egfr tki, overcomes t790m-mediated resistance to egfr inhibitors in lung cancer. cancer discov. 2014 sep;4(9):1046-61.

AZ-5104 Preparation Products And Raw materials

Raw materials

Preparation Products

AZ-5104 Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29879	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
CD Chemical Group Limited	58

View Lastest Price from AZ-5104 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	AZ-5104 1421373-98-9	US $48.00-125.00 / mg		99.9%	10g	TargetMol Chemicals Inc.
	2019-07-06	AZ-5104 1421373-98-9	US $1.00 / KG	1KG	98-100%	1000kg	Career Henan Chemical Co

AZ-5104
1421373-98-9
US $48.00-125.00 / mg
99.9%
TargetMol Chemicals Inc.

AZ-5104
1421373-98-9
US $1.00 / KG
98-100%
Career Henan Chemical Co

AZ-5104 Spectrum

AZ-5104(1421373-98-9)¹HNMR

1421373-98-9(AZ-5104)Related Search:

1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl- Osimertinib Impurity 7 Osimertinib Impurity N 2-Propenamide, N-[2-[[2-(dimethyloxidoamino)ethyl]methyloxidoamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-

1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-5-methoxy-N1-methyl-N1-[2-(methylmethyl-d3-amino)ethyl]- Osimertinib Impurity M N-(2-(dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide AZ 7550 1,4-Benzenediamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro-

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

1of3

N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide AZ5104 AZ-5104 N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide AZ7550 AZ5104; AZ-5104 N-[2-(2-dimethylaminoethylmethylamino)-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide AZD5104 AZ-5104;AZ 5104 CS-1709 N-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide Osimertinib Impurity A 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]- Demethylated AZ9291 metabolite of AZD9291 1421373-98-9 C27H31N7O2 Inhibitors