ChemicalBook >> CAS DataBase List >>2-(Trimethylsilyl)ethoxymethyl chloride
2-(Trimethylsilyl)ethoxymethyl chloride
- CAS No.
- 76513-69-4
- Chemical Name:
- 2-(Trimethylsilyl)ethoxymethyl chloride
- Synonyms
- SEM-CL;(2-trimethylethylsilylethoxy)methyl chloride;SEM-CI;2-(CHLOROMETHOXY)ETHYLTRIMETHYLSILANE;(Trimethylsilyl)ethoxymethyl chloride;DK891;2-(Trime;SEM-CHLORIDE;2-(triMethylsilyl)ethoxyMethyl chl;2-ChloroethoxyMethyltrimethylsilane
- CBNumber:
- CB1275117
- Molecular Formula:
- C6H15ClOSi
- Molecular Weight:
- 166.72
- MDL Number:
- MFCD00009919
- MOL File:
- 76513-69-4.mol
- MSDS File:
- SDS
Last updated:2024-11-15 19:19:13
| Boiling point | 170-172 °C (lit.) 57-59 °C/8 mmHg (lit.) |
|---|---|
| Density | 0.942 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 116 °F |
| storage temp. | 2-8°C |
| solubility | Sol most organic solvents (pentane, CH2Cl2, Et2O, THF, DMF, DMPU, HMPA) |
| form | Liquid |
| Specific Gravity | 0.95 |
| color | Clear colorless |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 3587289 |
| Stability | Unstable in Solution |
| InChIKey | BPXKZEMBEZGUAH-UHFFFAOYSA-N |
| CAS DataBase Reference | 76513-69-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 10-34 | |||||||||
| Safety Statements | 26-28-36/37/39-45-16 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
2-(Trimethylsilyl)ethoxymethyl chloride price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 238902 | 2-(Trimethylsilyl)ethoxymethyl chloride technical grade | 76513-69-4 | 1g | $57.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 238902 | 2-(Trimethylsilyl)ethoxymethyl chloride technical grade | 76513-69-4 | 5g | $154 | 2024-03-01 | Buy |
| TCI Chemical | C1339 | 2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine) >95.0%(GC) | 76513-69-4 | 5mL | $134 | 2024-03-01 | Buy |
| TCI Chemical | C1339 | 2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine) >95.0%(GC) | 76513-69-4 | 25mL | $457 | 2024-03-01 | Buy |
| Alfa Aesar | H55074 | 2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.1% N,N-Diisopropylethylamine | 76513-69-4 | 1g | $36.65 | 2024-03-01 | Buy |
2-(Trimethylsilyl)ethoxymethyl chloride Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liqui
Physical properties
bp 57–59 °C/8 mmHg; d 0.942 g cm?3.
Uses
2-(Trimethylsilyl)ethoxymethyl Chloride is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole, indole, and pyrrole nitrogens;electrophilic formaldehyde equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.
Uses
2-(Chloromethoxy)ethyltrimethylsilane is used in the preparation of SEM [2-(trimethylsilyl)ethoxy]methyl]-ethers. It serves as a phenol protecting group in the synthesis of laterifluorones. Further, it reacts with 1H-imidazole to prepare 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole.
General Description
2-(Trimethylsilyl)ethoxymethyl chloride (SEM-Cl) is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent.
Purification Methods
Dissolve SEMCl in pentane, dry it (MgSO4), evaporate and distil the residual oil in a vacuum. Stabilise it with 10ppm of diisopropylamine. Store it under N2 in a sealed container in a refrigerator. [Lipshutz & Pegram Tetrahedron Lett 21 3343 1980.]
Synthesis of 2-(Trimethylsilyl)ethoxymethyl chloride from Chlorotrimethylsilane and 1-BROMO-2-CHLOROMETHOXY-ETHANE
2-(Trimethylsilyl)ethoxymethyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazole
5H-Pyrrolo[3,2-d]pyrimidine, 2-chloro-5-[[2-(trimethylsilyl)ethoxy]methyl]-
1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Benzo[D]Imidazole
2-((2-(triMethylsilyl)ethoxy)Methoxy)propanoic acid
1H-Imidazole, 2-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-
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Global( 404)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 998 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18775 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
Related articles
- Protective effect of 2-(trimethylsilyl)ethoxymethyl chloride
- The 2-(trimethylsilyl)ethoxymethyl ether (SEM) has appeal a suitable substitute. This protecting group is stable to base and a....
- Mar 30，2022
View Lastest Price from 2-(Trimethylsilyl)ethoxymethyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-15 | 2-(Trimethylsilyl)ethoxymethyl chloride
76513-69-4
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-04-28 | 2-(Trimethylsilyl)ethoxymethyl chloride
76513-69-4
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-11-16 | 2-(Trimethylsilyl)ethoxymethyl chloride
76513-69-4
|
US $35.00-25.00 / kg | 1kg | 99% | 20 Ton | Hebei Xinsheng New Material Technology Co., LTD. |
-
- 2-(Trimethylsilyl)ethoxymethyl chloride
76513-69-4
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- 2-(Trimethylsilyl)ethoxymethyl chloride
76513-69-4
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 2-(Trimethylsilyl)ethoxymethyl chloride
76513-69-4
- US $35.00-25.00 / kg
- 99%
- Hebei Xinsheng New Material Technology Co., LTD.
76513-69-4(2-(Trimethylsilyl)ethoxymethyl chloride)Related Search:
SEM-CHLORIDE
2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE
CHLOROMETHYL 2-TRIMETHYLSILYLETHYL ETHER
2-(Trimethylsilyl)ethoxymethyl chloride ,95% [0.1% diisopropylethylamine as stabilizer]
2-(triMethylsilyl)ethoxyMethyl chl
2-(ChloroMethoxy)ethyltriMethylsilane, tech.
SEM-Chloride
2-(Trimethylsilyl)ethoxymethyl Chloride
SEM-Cl 2-(TriMethylsilyl)ethoxyMethyl chloride
2-(ChloroMethoxy)ethyltriMethylsilane, tech. 90%, stab. with 0.3% N-ethyldiisopropylaMine
2-(TriMethsilyl)-ethoxyMethyl chloride
2-(TriMethylsilyl)ethoxyMethyl Chloride, Stabilized with N,N-Dicyclohexyl-3-pentylaMine
2-(TriMethylsilyl)ethoxyMethyl chloride, stabilized with 10 ppM N,N-diisopropylethylaMine
2-(TriMethylsilyl)ethoxyMethyl chloride >=95.0% (GC)
2-(Chloromethoxy)ethyltrimethylsilane, stabilized with 0.3% N-ethyldiisopropylamine
2-chloromethyl 2-(trimethylsilyl)ethyl ether
2-(Trimethylsilyl)ethoxymethyl chloride, technical grade
2-(TRIMETHYSILYL)-ETHOXYMETHYL CHLORIDE
2-(Trimethylsilyl)ethoxymethylchloride,stabilized,tech.
2-(Trimethylsilyl)ethoxymethyl chloride, tech., stabilized, 90%
2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl)
2-ChloroethoxyMethyltrimethylsilane
-(trimethysilyl)-ethoxymethylchloride
Silane, 2-(chloromethoxy)ethyltrimethyl-
{2-[(chloromethyl)oxy]ethyl}(trimethyl)silane
2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)
2-(Trimethylsilyl)ethoxymethyl chloride, 90%, tech, stabilized
[2-(Trimethylsilyl)ethyl](chloromethyl) ether
2-(Trimethylsilyl)ethyl(chloromethyl) ether
2-(TRIMETHYLSILYL)ETHOXYMETHYLCHLORIDE , STABILIZED WITH IPR2MEN
(2-Chloromethoxyethyl)trimethylsilane, Chloromethyl 2-trimethylsilylethyl ether, SEM-chloride, SEM-Cl
2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.3% N-ethyldiisopropylamine
colorless liquid
2-(Trimethylsilyl)ethoxymethyl chloride, 95%, stabilized with 10 ppm N,N-diisopropylethylamine
2-(Trime
2-(Chloromethoxyethyl)trimethyl silane - stabilized with ca. 0.1% Diisopropylethylamine
2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)>
2-(Trimethylsilyl)ethoxymethyl Chloride，>95%
SEM-CI
SEM-CL
2-(CHLOROMETHOXY)ETHYLTRIMETHYLSILANE
(Trimethylsilyl)ethoxymethyl chloride
(2-trimethylethylsilylethoxy)methyl chloride
2-chloroMethyl 2-(triMethylsilyl)ethyl ethe
4,4'-METHYLENEBIS(7-BROMO-N,N-DIMETHYLANILINE)
DK891
SEM-CHLORIDE ~9% (2-(Trimethylsilyl)ethoxymethyl chloride)
Chloromethyl trimethylsilethyl ether
2-trimethylsilyl) thoxymethyl chloride
2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE
(2-Chloromethoxyethyl)trimethylsilane, Chloromethyl 2-trimethylsilylethyl ether, SEM-Cl, SEM-chloride
76513-69-4
76512-69-4
C6H15ClOSi
CH33SiCH2CH2OCH2Cl
Si (Classes of Silicon Compounds)
Protection & Derivatization Reagents (for Synthesis)
Si-(C)4 Compounds
Reagents for Oligosaccharide Synthesis
Silicon Compounds (for Synthesis)
Protecting and Derivatizing Reagents