ChemicalBook >> CAS DataBase List >>Propargyl-PEG3-NHS ester
Propargyl-PEG3-NHS ester
- CAS No.
- 1428629-71-3
- Chemical Name:
- Propargyl-PEG3-NHS ester
- Synonyms
- Alkyne-PEG3-NHS;Propargyl-PEG2-Osu;Propargyl-PEG3-NHS ester;Propargyl-PEG2-CH2CH2COONHS;Propargyl-PEG2-C2-CONHS ester;(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber:
- CB13049421
- Molecular Formula:
- C14H19NO7
- Molecular Weight:
- 313.3
- MDL Number:
- MFCD23726610
- MOL File:
- 1428629-71-3.mol
Last updated:2024-10-23 13:36:13
| Boiling point | 427.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.26±0.1 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| form | Liquid |
| color | Colorless to light yellow |
| InChI | InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2 |
| InChIKey | YDRPXORAOIYIGV-UHFFFAOYSA-N |
| SMILES | C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HS Code | 2942000090 |
Propargyl-PEG3-NHS ester price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P839588 | Propargyl-PEG3-NHSester | 1428629-71-3 | 10mg | $65 | 2021-12-16 | Buy |
| TRC | P839588 | Propargyl-PEG3-NHSester | 1428629-71-3 | 50mg | $220 | 2021-12-16 | Buy |
| TRC | P839588 | Propargyl-PEG3-NHSester | 1428629-71-3 | 100mg | $350 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | POL0002522 | PROPARGYL-PEG3-NHS ESTER 95.00% | 1428629-71-3 | 100MG | $236.25 | 2021-12-16 | Buy |
| BroadPharm | BP-21613 | Propargyl-PEG3-NHSester 98% | 1428629-71-3 | 500mg | $560 | 2021-12-16 | Buy |
Propargyl-PEG3-NHS ester Chemical Properties,Uses,Production
Description
Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc.
Biological Activity
Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Propargyl-PEG3-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 61)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
View Lastest Price from Propargyl-PEG3-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Propargyl-PEG3-NHS ester
1428629-71-3
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-03-26 | Propargyl-PEG3-NHS ester
1428629-71-3
|
US $0.00 / g | 5g | >98.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG3-NHS ester
1428629-71-3
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- Propargyl-PEG3-NHS ester
1428629-71-3
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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1of4
Propargyl-PEG3-NHS ester
Alkyne-PEG3-NHS
Propargyl-PEG2-CH2CH2COONHS
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate
Propargyl-PEG2-Osu
Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
Propargyl-PEG2-C2-CONHS ester
(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate
1428629-71-3
peg