BAY-1217389
- CAS No.
- 1554458-53-5
- Chemical Name:
- BAY-1217389
- Synonyms
- CS-2361;AY-1217389;BAY-1217389;BAY1217389, 10 mM in DMSO;BAY-1217389 BAY 1217389， BAY 1217389）;Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-
- CBNumber:
- CB13121923
- Molecular Formula:
- C27H24F5N5O3
- Molecular Weight:
- 561.5
- MDL Number:
- MFCD30502614
- MOL File:
- 1554458-53-5.mol
| Density | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 15 mg/ml |
| form | A crystalline solid |
| pka | 14.58±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | M964LB1114 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
BAY-1217389 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21660 | BAY 12-17389 ≥98% | 1554458-53-5 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 21660 | BAY 12-17389 ≥98% | 1554458-53-5 | 5mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 21660 | BAY 12-17389 ≥98% | 1554458-53-5 | 10mg | $266 | 2024-03-01 | Buy |
| Cayman Chemical | 21660 | BAY 12-17389 ≥98% | 1554458-53-5 | 25mg | $442 | 2024-03-01 | Buy |
| TRC | C992030 | N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide | 1554458-53-5 | 10mg | $440 | 2021-12-16 | Buy |
BAY-1217389 Chemical Properties,Uses,Production
Uses
N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide inhibits monopolar spindle 1, which is a serine/threonine/tyrosine kinase involved in cell division. It is also a potential antitumor agent.
in vivo
BAY 1217389 achieves moderate efficacy in monotherapy in tumor xenograft studies. However, in line with its unique mode of action, when combines with paclitaxel, low doses of Mps1 inhibitor reduces paclitaxel-induced mitotic arrest in line with weakening of SAC activity. As a result, combination therapy strongly improves efficacy over paclitaxel or Mps1 inhibitor monotreatment at the respective MTDs in a broad range of xenograft models including those showing acquired or intrinsic paclitaxel-resistance. BAY 1217389 shows good tolerability without adding toxicity to paclitaxel monotherapy[1].
IC 50
Mps1: 0.63 nM (IC50)
BAY-1217389 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-1217389 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
View Lastest Price from BAY-1217389 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | BAY1217389
1554458-53-5
|
US $33.00-76.00 / mg | 98.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-02 | BAY1217389
1554458-53-5
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- BAY1217389
1554458-53-5
- US $33.00-76.00 / mg
- 98.78%
- TargetMol Chemicals Inc.
-
- BAY1217389
1554458-53-5
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co