ChemicalBook >> CAS DataBase List >>INCB-047775
INCB-047775
- CAS No.
- 1430056-54-4
- Chemical Name:
- INCB-047775
- Synonyms
- AKT-IN-6;INCB-047775;AKT IN 6,AKTIN6;1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl-
- CBNumber:
- CB13168500
- Molecular Formula:
- C22H20FN5O
- Molecular Weight:
- 389.43
- MDL Number:
- MFCD30470660
- MOL File:
- 1430056-54-4.mol
Last updated:2024-07-02 08:55:00
INCB-047775 Chemical Properties,Uses,Production
Biological Activity
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].
References
[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1. [2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.
INCB-047775 Preparation Products And Raw materials
Raw materials
Preparation Products
INCB-047775 Suppliers
Global( 13)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39004 | 58 |
| Aikon International Limited | 025-66113011 18112977050 | cb6@aikonchem.com | China | 15494 | 58 |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1645 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 6828 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 4000255188 | sales@pharmablock.com | China | 7268 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 4997 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9266 | 58 |
INCB-047775
1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl-
AKT-IN-6
AKT IN 6,AKTIN6
1430056-54-4