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BLU-285

BLU-285 Structure
BLU-285 structure
CAS No.
1703793-34-3
Chemical Name:
BLU-285
Synonyms
Avapritinib;BLU-N;CS-2474;CPD1212;BLU-285;abaprotinib;Avapritinib(BLU-285);13C,2H3]-Avapritinib;BLU-285 (Avapritinib);BLU-285;BLU 285;BLU285
CBNumber:
CB13171751
Molecular Formula:
C26H27FN10
Molecular Weight:
498.56
MDL Number:
MFCD31544325
MOL File:
1703793-34-3.mol
Last updated:2024-07-18 18:48:45
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BLU-285 Properties

Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
form A crystalline solid
pka 6.96±0.10(Predicted)
color White to light yellow
InChIKey DWYRIWUZIJHQKQ-JKXWNSIXNA-N
SMILES C1N(C2N=CC([C@@](N)(C3C=CC(F)=CC=3)C)=CN=2)CCN(C2C3=CC(C4C=NN(C)C=4)=CN3N=CN=2)C1 |&1:6,r|
CAS DataBase Reference 1703793-34-3
NCI Dictionary of Cancer Terms avapritinib
FDA UNII 513P80B4YJ
NCI Drug Dictionary avapritinib
ATC code L01EX18

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H315-H317-H319-H332-H334-H340-H350-H360-H373-H412
Precautionary statements  P201-P202-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P308+P313-P342+P311-P362+P364-P403-P501c
NFPA 704
0
3 0

BLU-285 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22985 BLU-285 ≥98% 1703793-34-3 1mg $32 2024-03-01 Buy
Cayman Chemical 22985 BLU-285 ≥98% 1703793-34-3 5mg $161 2024-03-01 Buy
Cayman Chemical 22985 BLU-285 ≥98% 1703793-34-3 10mg $283 2024-03-01 Buy
Cayman Chemical 22985 BLU-285 ≥98% 1703793-34-3 25mg $618 2024-03-01 Buy
ChemScene CS-7577 Avapritinib 99.94% 1703793-34-3 25mg $690 2021-12-16 Buy
Product number Packaging Price Buy
22985 1mg $32 Buy
22985 5mg $161 Buy
22985 10mg $283 Buy
22985 25mg $618 Buy
CS-7577 25mg $690 Buy

BLU-285 Chemical Properties,Uses,Production

Description

BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor α (PDGFRα) tyrosine kinases with activating loop mutations (IC50s = 0.27 and 0.24 nM for KITD816V and PDGFRαD842V, respectively). It is >150-fold selective for KITD816V and PDGFRαD842V over a kinase panel at a concentration of 3 μM. BLU-285 also has activity against a panel of KIT and PDGFRα loop mutants identified in patients with gastrointestinal stromal tumors (GISTs; IC50s = <100 nM). It inhibits growth of cancer cell lines containing wild-type and mutant KIT and PDGFRα, demonstrating increased potency in cell lines expressing KIT and PDGFRα with activating loop mutations. BLU-285 (0.3-30 mg/kg) reduces tumor volume in a P815 KITD814Y mastocytoma allograft mouse model and a GIST patient-derived mouse xenograft model in a dose-dependent manner. Formulations containing BLU-285 have been used to treat KIT- and PDGFRα-driven malignancies.

Uses

Avapritinib is a medication used for the treatment of tumors due to one specific rare mutation. Avapritinib is a potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor.

Indications

Avapritinib is approved for the treatment of adult patients with unresectable or metastatic gastrointestinal mesenchymal stromal tumour (GIST) carrying platelet-derived growth factor receptor A (PDGFRA) exon 18 mutations, including the D842V mutation, as well as adult patients with advanced systemic mastocytosis (ASM).

brand name

Ayvakit

General Description

Class: receptor tyrosine kinase; Treatment: GIST, SM; Other name: BLU-285; Elimination half-life = 32–57 h; Protein binding = 98.8%

target

Primary targets: PDGFRA, KIT

BLU-285 Preparation Products And Raw materials

Raw materials

Preparation Products

BLU-285 Suppliers

Global( 116)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10310 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Wuhan Nutra Biotechnology Co.,Ltd 		+8617786394783 nutrabiotech@outlook.com China 300 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
career henan chemical co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
Wuhan Nutra Biotechnology Co.,Ltd 		58
Finetech Industry Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Limited 		58

Related articles

  • Synthesis of Avapritinib
  • The synthesis of Avapritinib occurs in two steps and requires the involvement of the intermediate Avapritinib Amine Salt.
  • Dec 28，2023

View Lastest Price from BLU-285 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Avapritinib pictures 2024-11-18 Avapritinib
1703793-34-3
 US $0.00 / g 1g More Than 99% 50kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
BLU-285 pictures 2019-12-25 BLU-285
1703793-34-3
 US $1.00 / g 1g 99% 1000KGS Career Henan Chemical Co
  • Avapritinib pictures
  • Avapritinib
    1703793-34-3
  • US $0.00 / g
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • BLU-285 pictures
  • BLU-285
    1703793-34-3
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

1703793-34-3(BLU-285)Related Search:

BLU 9931 BLU-945 BLU-782 Pralsetinib
BLU-285 CPD1212 (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine Avapritinib(BLU-285) BLU-285 (Avapritinib) BLU-285;BLU 285;BLU285 CS-2474 BLU-N (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine Avapritinib/CPD1212/Blu285 (S)-alpha-(4-Fluorophenyl)-alpha-methyl-2-[4-[6-(1-methyl-4-pyrazolyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl]pyrimidine-5-methanamine 5-Pyrimidinemethanamine, α-(4-fluorophenyl)-α-methyl-2-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl]-, (αS)- abaprotinib Avapritinib Avapritinib (Synonyms: BLU-285) 13C,2H3]-Avapritinib 1703793-34-3 API