ChemicalBook >> CAS DataBase List >>SKLB-1028
SKLB-1028
- CAS No.
- 1350544-93-2
- Chemical Name:
- SKLB-1028
- Synonyms
- SKLB-1028;ruserontinib;SKLB 1028, 10 mM in DMSO;9-isopropyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-8-(pyridin-3-yl)-9H-purine;9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine;9H-Purine-2,8-diamine, 9-(1-methylethyl)-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-3-pyridinyl-
- CBNumber:
- CB13303949
- Molecular Formula:
- C24H29N9
- Molecular Weight:
- 443.55
- MDL Number:
- MFCD30471083
- MOL File:
- 1350544-93-2.mol
Last updated:2025-04-17 18:22:24
| Boiling point | 671.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| pka | 7.89±0.42(Predicted) |
| form | Solid |
| color | Off-white to yellow |
| FDA UNII | AQ3TTU8UM7 |
SKLB-1028 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 2891DM | 2-N-[4-(4-Methylpiperazin-1-yl)phenyl]-9-propan-2-yl-8-N-pyridin-3-ylpurine-2,8-diamine | 1350544-93-2 | 100mg | $946 | 2021-12-16 | Buy |
| Ambeed | A536874 | 9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine 97% | 1350544-93-2 | 250mg | $1308 | 2021-12-16 | Buy |
| Ambeed | A536874 | 9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine 97% | 1350544-93-2 | 50mg | $365 | 2021-12-16 | Buy |
SKLB-1028 Chemical Properties,Uses,Production
Uses
SKLB-??1028 is a multikinase inhibitor with exceptional activity in models of FLT3-??driven acute myeloid leukemia and considerable potency in chronic myeloid leukemia that harbors Abl mutations.
in vivo
Ruserontinib (SKLB1028) (5-70 mg/kg, orally once daily, 18 days) have anti-tumor effect in MV4-11 and K562 xenograft NOD-SCID models[1].
| Animal Model: | MV4-11 and K562 xenograft NOD-SCID models[1] |
| Dosage: | 5, 10, 20 mg/kg,70 mg/kg |
| Administration: | orally once daily, 18 days |
| Result: | Prevented tumor growth at a dose of 5 mg/kg, and caused rapid and complete tumor regression in both groups of mice at a dose of 10 or 20 mg/kg. Significantly inhibited the proliferation and induced apoptosis of MV4-11 and K562 cells at a dose of 70 mg/kg. |
SKLB-1028 Preparation Products And Raw materials
Raw materials
Preparation Products
SKLB-1028 Suppliers
Global( 15)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9475 | 58 |
| Hebei Weite Medical Technology Co., Ltd | 13180081292 | contact@wetogethermed.com | China | 7839 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24642 | 58 |
| Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd | 13732973797; 13732973797 | liu@zybiopharma.com | China | 304 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9266 | 58 |
SKLB-1028
9-isopropyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-8-(pyridin-3-yl)-9H-purine
9H-Purine-2,8-diamine, 9-(1-methylethyl)-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-3-pyridinyl-
9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine
ruserontinib
SKLB 1028, 10 mM in DMSO
1350544-93-2
C24H29N9