OXINDOLE I
- CAS No.
- Chemical Name:
- OXINDOLE I
- Synonyms
- OXINDOLE I;3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDROINDOL-2-ONE
- CBNumber:
- CB1330427
- Molecular Formula:
- C13H10N2O
- Molecular Weight:
- 210.23
- MDL Number:
- MFCD00118215
- MOL File:
- Mol file
OXINDOLE I Chemical Properties,Uses,Production
Enzyme inhibitor
This indole derivative (FW = 210.24 g/mol), also known as oxindole I, is a potent and selective inhibitor of the vascular endothelial growth factor (VEGF) receptor protein-tyrosine kinase Flk-1 (i.e., fetal liver kinase-1), IC50 = 390 nM, but a weaker inhibitor of platelet-derived growth factor receptor (PDGFR) protein-tyrosine kinase, IC50 = 12 μM. In addition, it also inhibits certain cyclin-dependent kinases: cyclin D1/cdk4 enzyme (IC50 = 4.9 μM) > cyclin E/cdk2 (IC50 = 10 μM) and cyclin B/cdk1 (IC50 = 10.2 μM).
OXINDOLE I Preparation Products And Raw materials
Raw materials
Preparation Products
OXINDOLE I Suppliers
Global( 11)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Taize Jiaye Technology Development Co., Ltd. | -- | CHINA | 6050 | 58 | |
| Shanghai Yijie Biological Technology Co., Ltd. | -- | SHYIJIEBIO@126.COM | CHINA | 3510 | 58 |
| Xiamen Huijia Biological Technology Co., Ltd. | -- | CHINA | 6979 | 58 | |
| Shanghai Haoran Biotechnology Co., Ltd. | -- | 470003480@QQ.COM | CHINA | 6968 | 58 |
| Absin Bioscience Inc. | -- | chenjw@absin.cn | CHINA | 6661 | 58 |
| Beijing Taize Ruida Technology Co., Ltd. | -- | taizeorder@163.com | CHINA | 6536 | 58 |
| Beijing Bi Orange Blue Biotechnology Co., Ltd. | -- | bo49855987@163.com | CHINA | 6827 | 58 |
| Beijing Zhijie Fangyuan Technology Co., Ltd. | -- | 15810200961@163.com | CHINA | 6984 | 58 |
| Kanto Chemical Co., Inc. | -- | reag-info@gms.kanto.co.jp | Japan | 6762 | 74 |
| EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
(OXINDOLE I)Related Search:
OXINDOLE I
3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDROINDOL-2-ONE