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2-Amino-5-chlorobenzophenone

2-Amino-5-chlorobenzophenone Structure
2-Amino-5-chlorobenzophenone structure
CAS No.
719-59-5
Chemical Name:
2-Amino-5-chlorobenzophenone
Synonyms
(2-AMINO-5-CHLOROPHENYL)(PHENYL)METHANONE;ACB;Alprazolam Impurity 4;4-CHLORO-2-BENZOYLANILINE;2--5-;NSC 84157;2-Amino-5-chloro;IFLAB-BB F1386-0355;TIMTEC-BB SBB003271;Nepafenac Impurity 3
CBNumber:
CB1335583
Molecular Formula:
C13H10ClNO
Molecular Weight:
231.68
MDL Number:
MFCD00007839
MOL File:
719-59-5.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
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2-Amino-5-chlorobenzophenone Properties

Melting point 96-98 °C (lit.)
Boiling point 207 °C
Density 1.33
vapor pressure 0-1Pa at 20-25℃
refractive index 1.6000 (estimate)
Flash point 211 °C
storage temp. Store below +30°C.
solubility Solubility in methanol gives very faint turbidity. Soluble in DMSO.
pka 0.06±0.10(Predicted)
form Crystalline Powder
color Yellow
BRN 475640
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey ZUWXHHBROGLWNH-UHFFFAOYSA-N
LogP 3.16 at 21℃ and pH7
CAS DataBase Reference 719-59-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII FR80014ZBT
NIST Chemistry Reference Benzophenone, 2-amino-5-chloro-(719-59-5)
EPA Substance Registry System Methanone, (2-amino-5-chlorophenyl)phenyl- (719-59-5)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  PC4933500
TSCA  Yes
HS Code  29223900
Toxicity LD50 orally in Rabbit: 10000 mg/kg
NFPA 704
0
2 0

2-Amino-5-chlorobenzophenone price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A45564 2-Amino-5-chlorobenzophenone 98% 719-59-5 25g $46 2024-03-01 Buy
Sigma-Aldrich 1022808 2-Amino-5-chlorobenzophenone United States Pharmacopeia (USP) Reference Standard 719-59-5 25mg $1490 2024-03-01 Buy
TCI Chemical A0079 2-Amino-5-chlorobenzophenone >98.0%(T) 719-59-5 25g $46 2024-03-01 Buy
TCI Chemical A0079 2-Amino-5-chlorobenzophenone >98.0%(T) 719-59-5 500g $545 2024-03-01 Buy
Alfa Aesar A15720 2-Amino-5-chlorobenzophenone, 98+% 719-59-5 100g $37.65 2024-03-01 Buy
Product number Packaging Price Buy
A45564 25g $46 Buy
1022808 25mg $1490 Buy
A0079 25g $46 Buy
A0079 500g $545 Buy
A15720 100g $37.65 Buy

2-Amino-5-chlorobenzophenone Chemical Properties,Uses,Production

Chemical Properties

yellow powder

Uses

It is used in the heterocyclic syntheses based on the reactions of dimethyl acetylenedicarboxylate.

Uses

A metabolite of Diazepam; it had a much weaker anticonvulsant effect.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9

General Description

2-Amino-5-chlorobenzophenone is a organic nonlinear optical material.

Synthesis

5-CHLORO-3-PHENYLANTHRANIL

719-64-2

2-Amino-5-chlorobenzophenone

719-59-5

(2) 10.0 g of intermediate (II) was added to a three-necked flask containing 50 mL of ethanol, 4.8 g of iron powder was added, and refluxed for 0.5 hours. Subsequently, 1 mL of 6 mol/L sulfuric acid solution was slowly added dropwise. After the dropwise addition, the reaction was continued to reflux for 1 hour. After the reaction was completed, the pH of the reaction solution was adjusted to 8 with NaOH solution and cooled to 50 °C. Add 0.2 g of activated carbon and reflux for 0.5 h. Perform hot filtration into a crystallization flask and cool the crystals. The crystals were washed with ethanol and dried to give 9.60 g of intermediate (III) in 95.1% yield, melting point 96.3-98.2 °C.

References

[1] Journal of Chemical Research - Part S, 2002, # 12, p. 601 - 603
[2] Patent: CN108250091, 2018, A. Location in patent: Paragraph 0032; 0034; 0040
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 690 - 691
[4] Patent: CN106083621, 2016, A. Location in patent: Paragraph 0021-0025
[5] Patent: CN107935872, 2018, A. Location in patent: Paragraph 0034-0063; 0067-0074

2-Amino-5-chlorobenzophenone synthesis

719-64-2
719-59-5
Synthesis of 2-Amino-5-chlorobenzophenone from 5-CHLORO-3-PHENYLANTHRANIL

2-Amino-5-chlorobenzophenone Preparation Products And Raw materials

Raw materials

4-Chloronitrobenzene phenylacetonitrile 2-Furoic acid Glass-lined reaction pot Isoxazole
Zinc chloride Water 4-Chloroaniline Benzoyl chloride Benzamide

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Preparation Products

1-(6-CHLORO-2-HYDROXY-4-PHENYL-QUINOLIN-3-YL)-ETHANONE Chlordiazepoxide 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate (6-CHLORO-2-METHYL-4-PHENYLQUINOLIN-3-YL)ACETIC ACID 2-AMINO-5-CHLOROBENZOPHENONE OXIME
Demoxepam 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE Diazapam ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE 6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline
2-amino-5-chloro-alpha-methylbenzhydryl alcohol DIETHYL 2-[(2-BENZOYL-4-CHLOROANILINO)METHYLENE]MALONATE

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2-Amino-5-chlorobenzophenone Suppliers

Global( 644)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3178 58
Hebei Mujin Biotechnology Co.,Ltd 		+86-13288715578 sales@hbmojin.com China 12648 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5251 58
hebei hongtan Biotechnology Co., Ltd 		+852-6619 3215 +86-17731935328 sales03@chemcn.cn China 970 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29731 60
Dalian Richfortune Chemicals Co., Ltd 		+86-86-411-84820922 +86-8613904096939 sales@richfortunechem.com China 131 57
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
hebei hongtan Biotechnology Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Dalian Richfortune Chemicals Co., Ltd 		57
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55

Related articles

View Lastest Price from 2-Amino-5-chlorobenzophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-5-chlorobenzophenone pictures 2025-07-30 2-Amino-5-chlorobenzophenone
719-59-5
 0.99 RongNa Biotechnology Co.,Ltd
2-Amino-5-chlorobenzophenone pictures 2025-07-30 2-Amino-5-chlorobenzophenone
719-59-5
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Amino-5-chlorobenzophenone pictures 2025-07-29 2-Amino-5-chlorobenzophenone
719-59-5
 US $105.00 / ASSAYS 1ASSAYS 98% 1-1000kg Baoji Guokang Bio-Technology Co., Ltd.

2-Amino-5-chlorobenzophenone Spectrum

2-Amino-5-chlorobenzophenone(719-59-5)MS2-Amino-5-chlorobenzophenone(719-59-5)1HNMR2-Amino-5-chlorobenzophenone(719-59-5)13CNMR2-Amino-5-chlorobenzophenone(719-59-5)IR12-Amino-5-chlorobenzophenone(719-59-5)IR22-Amino-5-chlorobenzophenone(719-59-5)Raman

719-59-5(2-Amino-5-chlorobenzophenone)Related Search:

Phenylhydrazine Benzophenone 4-Chlorobenzophenone (3,4-Diaminophenyl)phenylmethanone Betaine
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Difluorochloromethane 2-Amino-2',5-dichlorobenzophenone 2-Cyclopropylmethylamino-5-chlorobenzophenone Pigment Red 202 2-Amino-5-chloro-2'-fluorobenzophenone
2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 5-Chloro-2-(methylamino)benzophenone 2-AMINO-5-CHLOROBENZOPHENONE /CHLORDIAZEPOXIDE

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5-CHLORO-2-AMINOBENZOPHENONE LABOTEST-BB LT00259286 IFLAB-BB F1386-0355 2-Amino-5-chlorobenophenone 2-AMINO-5-CHLOROBENZOPHENONE 98% 2-Amino-5-chloro 2--5- 2-Amino-5-chlorobenzophenone ( for ALPRAZOLAM) 2-Amino-5-chlorobenzophenone, 98+% 2-Amino-5-chlorobenzophenone (25 mg) 2-AMino-5-chlorobenzophenone, 98% 100GR TIMTEC-BB SBB003271 2-AMINO-5-CHLOROBENZOPHENONE pure (2-amino-5-chlorophenyl)phenyl-methanon 2-Amino-5-chlorbenzophenon 2-Amino-5-chlorbenzophenone 2-Amino-5-chlorodiphenylone 2-Benzoyl-4-chloroaniline Methanone, (2-amino-5-chlorophenyl)phenyl- 2-AMino-5-chlorobenzylphenone NSC 84157 OxazepaM Benzophenone Benzophenone,2-aMino-5-chloro 2-AMINO-5-CHLOROBENZOPHENONE FOR SYNTHES 2-AMino-5-chlorobenophonene 2-AMino-5-chlorobenzophenone, 98+%, 98+% 2 - aMino - 5 - chlorine diphenyl ketone 2-AMINO-5-CHLOROBENZOPHENONE Chlordiazepoxide Impurity Ⅰ:2-Amino-5-chlorobenzophenone Nepafenac Impurity 3 Alprazolam Impurity 5（Alprazolam EP Impurity E） 2-Amino-5-chlorobenzophenone > Dipotassium clorazepate EP Impurity A Prazepam EP Impurity C Oxazepam EP Impurity D Chlordiazepoxide EP Impurity C Chlordiazepoxide impurity C Estazol Am Intermediate CAS 719-59-5 2-Amino-5-Chlorobenzophenone 4-CHLORO-2-BENZOYLANILINE (2-AMINO-5-CHLOROPHENYL)(PHENYL)METHANONE ACB Alprazolam Impurity 4 e . (2-a mi no-5-c h loroph e nyl)ph e nylme th a none Chlordiazepoxide Hydrochloride EP Impurity C Oxazepam EP impurity D (prazolam EP impurity E) 2-Amino-5-chlorodibenzophenone 2-Amino-5-Chlorobenzophenone (Alprazolam Impurity) 2-Amino-5-chlorobenzophenone in methanol Alprazolam Impurity E Prazepam Imp. C (EP), Clorazepate Imp. A (EP), , 2-Amino-5- chloro benzophenone 2-Amino-5-chlorobenzophenone 99.5% 719-59-5 H2NC6H3ClCOC6H5 Organic Building Blocks Ketones Building Blocks Carbonyl Compounds C13 to C14 AMINE