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METHOXAMINE HYDROCHLORIDE

METHOXAMINE HYDROCHLORIDE structure

CAS No.: 61-16-5

Chemical Name:: METHOXAMINE HYDROCHLORIDE

Synonyms: vasoxyl;Mexan;Vasylox;vasoxine;METHOXAMINE HCL;vasoxylhydrochloride;Naproxen Impurity 47;vasoxinehydrochloride;pressominhydrochloride;Methoxamine hydrochlorid

CBNumber:: CB1380846

Molecular Formula:: C11H18ClNO3

Molecular Weight:: 247.72

MDL Number:: MFCD00058607

MOL File:: 61-16-5.mol

MSDS File:: SDS

Last updated:2024-07-02 08:55:00

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METHOXAMINE HYDROCHLORIDE Properties

Melting point	215℃
refractive index	1.5204
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.2(at 25℃)
color	White to off-white
CAS DataBase Reference	61-16-5(CAS DataBase Reference)
FDA UNII	8MB4MJ9R7L

SAFETY

Risk and Safety Statements

WGK Germany	3
RTECS	DN4025000
Hazardous Substances Data	61-16-5(Hazardous Substances Data)

METHOXAMINE HYDROCHLORIDE price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M6524	Methoxamine hydrochloride	61-16-5	500mg	$187	2024-03-01	Buy
Sigma-Aldrich	M6524	Methoxamine hydrochloride	61-16-5	1g	$336	2024-03-01	Buy
TRC	M260740	MethoxamineHydrochloride(MixtureofDiastereomers)	61-16-5	250mg	$160	2021-12-16	Buy
American Custom Chemicals Corporation	API0003335	METHOXAMINE HYDROCHLORIDE 95.00%	61-16-5	0.5G	$538	2021-12-16	Buy
Medical Isotopes, Inc.	41303	MethoxamineHCl(MixtureofDiastereomers)	61-16-5	250mg	$650	2021-12-16	Buy

Product number	Packaging	Price	Buy
M6524	500mg	$187	Buy
M6524	1g	$336	Buy
M260740	250mg	$160	Buy
API0003335	0.5G	$538	Buy
41303	250mg	$650	Buy

METHOXAMINE HYDROCHLORIDE Chemical Properties,Uses,Production

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Uses

Methoxamine is an α1-adrenergic receptor agonist. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure.

Uses

Antihypotensive;Alpha adrenergic agonist

Uses

anti-fungal

Definition

ChEBI: Methoxamine hydrochloride is a dimethoxybenzene.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

Biochem/physiol Actions

α1-adrenoceptor agonist.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of HCl and NOx.

METHOXAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Hydrogen Nitrous acid methyl ester

Preparation Products

METHOXAMINE HYDROCHLORIDE Suppliers

Global( 107)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29793	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Unipharm pharmaceutical industry Co., Ltd	536-8266195 +8613953676784	lee@unipharm-sd.com	China	1202	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3095	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Unipharm pharmaceutical industry Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Dorne Chemical Technology co. LTD	58

View Lastest Price from METHOXAMINE HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-05	METHOXAMINE HYDROCHLORIDE 61-16-5	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

METHOXAMINE HYDROCHLORIDE
61-16-5
US $7.00 / KG
99%
Career Henan Chemical Co

61-16-5(METHOXAMINE HYDROCHLORIDE)Related Search:

2,5-Dimethoxyphenethylamine hydrochloride 2,5-DIMETHOXYBENZYL ALCOHOL 2-Methoxyphenethylamine Norfenefrine hydrochloride methoxamine

2-Amino-1-(2,5-dimethoxyphenyl)ethanol N-desmethylmethoxyphenamine Butoxamine hydrochloride METHOXAMINE HYDROCHLORIDE ISOPROPYLAMINE HYDROCHLORIDE

2-AMINO-1-(3-METHOXY-PHENYL)-ETHANOL HCL 2-(2-aminopropyl)phenol 2-amino-1-(3-methoxyphenyl)ethanol 2-AMINO-1-(2-METHOXY-PHENYL)-ETHANOL HCL 2-AMINO-1-(2-METHOXYPHENYL)ETHANOL

2-HYDROXY-5-METHOXYBENZYL ALCOHOL 1-(2,5-DIMETHOXYPHENYL)-2-AMINOPROPANEHYDROCHLORIDE 2-(2-aminoethyl)phenol

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vasoxylhydrochloride Methoxamine Hydrochloride (200 mg) 2-aMino-1-(2,5-diMethoxyphenyl)propan-1-ol hydrochloride MethoxaMine Hydrochloride (Mixture of DiastereoMers) BenzeneMethanol,a-(1-aMinoethyl)-2,5-diMethoxy-,hydrochloride (1:1) α-[1-Aminoethyl]-2,5-dimethoxybenzenemethanol hydrochloride α-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride 2-Amino-1-hydroxy-1-(2,5-dimethoxyphenyl)propane hydrochloride a-(a-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (9CI) Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (8CI) Beta-hydroxy-beta-(2,5-dimethoxyphenol)-isopropylamine hydrochloride b-Hydroxy-b-(2,5-dimethoxyphenyl)isopropylamine hydrochloride Vasylox Mexan ALPHA-[1-AMINOETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE 1-(2,5-dimethoxyphenyl)-2-aminopropanol 2-amino-1-(2,5-dimethoxyphenyl)-1-propanolhydrochloride alpha-(1-aminoethyl)-2,5-dimethoxy-benzenemethanohydrochloride alpha-(1-aminoethyl)-2,5-dimethoxybenzenemethanolhydrochloride alpha-(1-aminoethyl)-2,5-dimethoxy-benzylalcohohydrochloride Methoxamine hydrochlorid alpha-(alpha-aminoethyl)-2,5-dimethoxybenzylalcoholhydrochloride beta-(2,5-dimethoxyphenyl)-beta-hydroxyisopropylaminehydrochloride beta-hydroxy-beta-(2,5-dimethoxyphenyl)isopropylaminehydrochloride beta-hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylaminehydrochloride pressominhydrochloride vasoxine vasoxinehydrochloride METHOXAMINE HCL METHOXAMINE HYDROCHLORIDE Benzenemethanol,α-(1-aminoethyl)-2,5-dimethoxy-,hydrochloride(1:1) METHOXAMINE HYDROCHLORIDE USP/EP/BP Methoxamine hydrochloride salt vasoxyl Naproxen Impurity 47 61-16-5 C11H19Cl2NO3 alpha1-adrenoceptor agonist. A type adrenergic receptor stimulants