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Ramosetron hydrochloride

Ramosetron hydrochloride Structure
Ramosetron hydrochloride structure
CAS No.
132907-72-3
Chemical Name:
Ramosetron hydrochloride
Synonyms
ym060;Nasea OD;(R)-YM-060;RAMOSETRON HCL;YM-060;YM060;YM 060;(r)-monohydrochlorid;Ramosetron Hydrochlorid;Ramosetron hydrocloride;RAMOSETRON HYDROCHLORIDE;Ramosetron hydrochloride (API)
CBNumber:
CB1397525
Molecular Formula:
C17H18ClN3O
Molecular Weight:
315.8
MDL Number:
MFCD00894748
MOL File:
132907-72-3.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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Ramosetron hydrochloride Properties

Melting point 244-246°C
alpha D -42.9° (c 1.02 in methanol)
storage temp. -20°C
solubility H2O: soluble20mg/mL, clear
form powder
color white to beige
optical activity [α]/D -40 to -45°, c = 1 in methanol
Stability Hygroscopic
InChIKey XIXYTCLDXQRHJO-RFVHGSKJSA-N
CAS DataBase Reference 132907-72-3(CAS DataBase Reference)
FDA UNII 9551LHD87E
NCI Drug Dictionary ramosetron hydrochloride

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264; P270; P301+P312; P330; P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
Toxicity dog,LD,intravenous,> 30mg/kg (30mg/kg),SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE,Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994.
NFPA 704
0
2 0

Ramosetron hydrochloride price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0674 Ramosetron hydrochloride ≥98% (HPLC) 132907-72-3 10mg $91.6 2024-03-01 Buy
Sigma-Aldrich SML0674 Ramosetron hydrochloride ≥98% (HPLC) 132907-72-3 50mg $354 2024-03-01 Buy
Cayman Chemical 15548 Ramosetron (hydrochloride) ≥98% 132907-72-3 10mg $68 2024-03-01 Buy
Cayman Chemical 15548 Ramosetron (hydrochloride) ≥98% 132907-72-3 25mg $152 2024-03-01 Buy
Cayman Chemical 15548 Ramosetron (hydrochloride) ≥98% 132907-72-3 50mg $286 2024-03-01 Buy
Product number Packaging Price Buy
SML0674 10mg $91.6 Buy
SML0674 50mg $354 Buy
15548 10mg $68 Buy
15548 25mg $152 Buy
15548 50mg $286 Buy

Ramosetron hydrochloride Chemical Properties,Uses,Production

Description

Ramosetron Hydrochloride is the only currently available drug indicated for the treatment of male patients with IBS-D in Japan. Ramosetron Hydrochloride was approved in July 1996 under a brand name of Nasea Injection 0.3 mg and in June 1998 under a brand name of Nasea OD tablets 0.1 mg for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with therapy with antineoplastic drugs (e.g., cisplatin).
Nasea was launched in Japan for chemotherapy-induced emesis. Nasea was prepared by a four step sequence via the Vilsmeier-type coupling of 1-methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl-benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.

Chemical Properties

White Solid

Originator

Yamanouchi (Japan)

Uses

Ramosetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist and has structurally different from Ondansetron (O655000), Granisetron (G780000). It controls excessive bowel movement and diarrhea by inhibiting 5-HT3 receptors in the intestinal tract. Ramosetron Hydrochloride was approved as film-coated tablets in July 2008 and as orally disintegrating tablets in August 2013 for the indication of treatment of male patients with diarrhea-predominant irritable bowel syndrome.

Definition

ChEBI: Ramosetron hydrochloride is a member of indoles.

brand name

Nasea

Biochem/physiol Actions

Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively. this pharmacologic property confers the drug an application in improving diarrhea-predominant inflammatory bowel syndrome. Ramosetron hydrochloride is used for PONV prophylaxis and treatment. However, ramosetron is currently only licenced for use in Japan and selected Southeast Asian countries.

Ramosetron hydrochloride synthesis

132036-88-5
912850-42-1
912850-41-0
132907-72-3
Synthesis of Ramosetron hydrochloride from RAMOSETRON

Ramosetron hydrochloride Preparation Products And Raw materials

Raw materials

5-[(1-Methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-bezimidazole

Preparation Products

Ramosetron hydrochloride Suppliers

Global( 258)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 +86-17332992504 sales8@hbganmiao.com China 300 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368 sales@sjar-tech.com China 456 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
Supplier Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Hebei Ganmiao New material Technology Co., LTD 		58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from Ramosetron hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ramosetron Hydrochlorid pictures 2024-12-23 Ramosetron Hydrochlorid
132907-72-3
 US $0.00 / g 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Ramosetron hydrochloride pictures 2024-12-13 Ramosetron hydrochloride
132907-72-3
 US $0.00-0.00 / g 1g 98.5% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Ramosetron hydrochloride pictures 2024-11-19 Ramosetron hydrochloride
132907-72-3
 US $32.00-71.00 / mg 99.95% 10g TargetMol Chemicals Inc.

Ramosetron hydrochloride Spectrum

Ramosetron hydrochloride(132907-72-3)1HNMR

132907-72-3(Ramosetron hydrochloride )Related Search:

Topotecan hydrochloride RAMOSETRON Indole-3-butyric acid 1-AdaMantanethylaMine Indometacin
Benzimidazole Indole-3-acetic acid 3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one 1-Methyl-1H-indole-3-carboxylic acid
1-Methylindole Rasagiline Impurity 5 Mesylate 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one ramosetron 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride
Rasagiline Impurity 3 3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one Ramosetron Impurity 13

1of4

Methanone,(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]-,hydrochloride (1:1) (R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride RAMOSETRON HCL RAMOSETRON HYDROCHLORIDE (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon (r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr (r)-monohydrochlorid ym060 RAMOSETRON HYDROCHLORIDE 98.5% MIN (-)-5-(R)-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride Ramosetron Hydrochlorid Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)- Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-, monohydrochloride (9CI) (R)-YM-060 Nasea OD (R)-(1-Methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzo[d]iMidazol-6-yl)Methanone hydrochloride (1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]Methanone (1-methyl-3-indolyl)-(4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)methanone hydrochloride (1-METHYL-1H-INDOL-3-YL)[(5R)-4,5,6,7-TETRAHYDRO-1H-BENZIMIDAZOL-5-YL]METHANONE Ramosetron hydrocloride YM-060;YM060;YM 060 Ramosetron HydrochlorideQ: What is Ramosetron Hydrochloride Q: What is the CAS Number of Ramosetron Hydrochloride Q: What is the storage condition of Ramosetron Hydrochloride Q: What are the applications of Ramosetron Hydrochloride Ramosetron hydrochloride (API) 132907-72-3 C17H17N3OHCl C17H17N3OClH API Antiemetic Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals 132907-72-3