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Naphazoline hydrochloride

Naphazoline hydrochloride Structure
Naphazoline hydrochloride structure
CAS No.
550-99-2
Chemical Name:
Naphazoline hydrochloride
Synonyms
NAPHAZOLINE HCL;Naphazoline hydrochloride (Naphcon);4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;clera;niazol;coldan;naphcon;rhinoperd;rhinantin;stricylon
CBNumber:
CB1412136
Molecular Formula:
C14H14N2.ClH
Molecular Weight:
246.74
MDL Number:
MFCD00012554
MOL File:
550-99-2.mol
MSDS File:
SDS
Last updated:2024-10-31 18:15:48
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Naphazoline hydrochloride Properties

Melting point 254-260 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Freely soluble in water, soluble in ethanol (96 per cent).
form Crystalline Powder
pka pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03; pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03
color White
PH pH (50g/l, 25℃) : 4.0～6.0
Water Solubility 170 g/L (20 ºC)
Sensitive Hygroscopic
Merck 14,6368
BRN 3716843
Stability Hygroscopic
InChIKey DJDFFEBSKJCGHC-UHFFFAOYSA-N
CAS DataBase Reference 550-99-2(CAS DataBase Reference)
FDA 21 CFR 341.20
EWG's Food Scores 1
FDA UNII MZ1131787D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310+P330-P405-P501-P301+P310a-P321-P501a
Hazard Codes  T,Xn
Risk Statements  25-23/24/25-20/21/22
Safety Statements  45-36/37/39-24/25
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  NJ4375000
HazardClass  6.1
PackingGroup  III
HS Code  29339900
Hazardous Substances Data 550-99-2(Hazardous Substances Data)
Toxicity LD50 s.c. in rats: 385 mg/kg (Gylfe)
NFPA 704
1
3 0

Naphazoline hydrochloride price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N5504 Naphazoline hydrochloride 550-99-2 25g $72.3 2024-03-01 Buy
Sigma-Aldrich 1457006 Naphazoline hydrochloride United States Pharmacopeia (USP) Reference Standard 550-99-2 200mg $436 2024-03-01 Buy
TCI Chemical N0542 Naphazoline Hydrochloride >99.0%(T) 550-99-2 10g $25 2024-03-01 Buy
Alfa Aesar B24161 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride, 99% 550-99-2 25g $32.65 2024-03-01 Buy
Alfa Aesar B24161 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride, 99% 550-99-2 100g $81.65 2024-03-01 Buy
Product number Packaging Price Buy
N5504 25g $72.3 Buy
1457006 200mg $436 Buy
N0542 10g $25 Buy
B24161 25g $32.65 Buy
B24161 100g $81.65 Buy

Naphazoline hydrochloride Chemical Properties,Uses,Production

Pharmacological effects

Naphazoline hydrochloride, is commonly used as a vasoconstrictor in the hospital's otorhinolaryngology and ophthalmology ,it is a adrenomimetic drug ,it has a strong effect on contraction of blood vessels and blood pressure elevation,it has inhibition effect on the central nervous system,by contraction of local vascular, it can play an anti-inflammatory and analgesic role in the local inflammatory lesions , and can eliminate congestion due to fatigue or other reasons. Clinically it is used for the treatment of colds, acute and chronic rhinitis, allergic conjunctivitis, allergic and inflammatory nasal congestion embolism. Local long-term use can lead to blood flow reduction in medication area, which causes resistance decreasing , and results in superinfection. It can not be taken orally. Dropping excess liquid or high concentrations can cause poisoning. Care should be taken, especially in children. Infants, hypertension, hyperthyroidism patients should take with caution, atrophic rhinitis patients are banned. The interval time of dropping , is preferably not less than 4 to 6 hours.
The above information is edited by the chemicalbook of Tian Ye.

Chemical Properties

White crystalline powder. Melting point 255-260 ℃. 40 grams of the product can be dissolved in 100 ml of water . It is soluble in alcohol, slightly soluble in chloroform, insoluble in ether and benzene. Odorless, bitter taste.

Uses

This product is a vasoconstrictor. Rat subcutaneous injection is LD50 385 mg/kg.

Production method

By the α-naphthalene acetic acid and ethylene diamine condensation, cyclization ,2-(1-naphthylmethyl) imidazoline (C14H14N2, [835-31-4]) is made , then after salifying, naphazoline hydrochloride is derived . The α-acetic acid and ethylene diamine are added to the reaction pot, stir and heat to 120 ℃, react after 1 hour, then heat to 130 ℃, react for 1 hour. Ethylenediamine and water are distilled ,and after vacuum distillation, collect 180-240 ℃ (1.33-4 kPa) distillate, obtain 2-(1-naphthylmethyl) imidazoline. It is dissolved in a mixture of acetone and ethanol, and at 10-12℃ inlet hydrogen chloride gas to become into a salt, naphazoline hydrochloride crystals is generated .

Chemical Properties

White or almost white, crystalline powder.

Originator

Albalon,Allergan,Australia

Uses

antihistamine

Uses

adrenergic blocker

Uses

Naphazoline Hydrochloride is a useful synthetic intermediate used in eye drops. A vasoconstrictor.

Definition

ChEBI: Naphazoline is an organic molecular entity.

Manufacturing Process

2.7 parts of naphtyl-(1)-acetiminoethylether (produced from naphthyl-1- acetonitrile) were dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the mixture was heated to gentle boiling while passing it through nitrogen and simultaneously stirring until ammonia escaped no longer. The alcohol was is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring was continued for some time whereby the imidazoline base was dissolved in benzene. The benzene residue, is recrystallized several times from toluene. The 2-[naphthyl-1-methyl]-imidazoline represented the coloriless crystalls of melting point 252°-253°C. Its hydrochloride is easily soluble in water.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Vasoconstrictor, Nasal decongestant

Naphazoline hydrochloride synthesis

835-31-4
550-99-2
Synthesis of Naphazoline hydrochloride from Naphazoline

Naphazoline hydrochloride Preparation Products And Raw materials

Raw materials

1-Methylimidazole 1-Naphthaleneacetic acid Imidazolidine Ethylenediamine

Preparation Products

Naphazoline hydrochloride Suppliers

Global( 502)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12837 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18152 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Wuhan Quanjinci New Material Co.,Ltd. 		+86-15271838296; +8615271838296 kyra@quanjinci.com China 1512 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20285 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18751 58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951 CHINA 115 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Weibang Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Wuhan Quanjinci New Material Co.,Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

View Lastest Price from Naphazoline hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Naphazoline hydrochloride pictures 2024-12-13 Naphazoline hydrochloride
550-99-2
 US $1.00 / KG 1KG 99.00%-101.00%,USP/BP 1ton/month WUHAN FORTUNA CHEMICAL CO., LTD
Naphazoline hydrochloride pictures 2024-10-31 Naphazoline hydrochloride
550-99-2
 US $0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
Naphazoline hydrochloride pictures 2024-10-25 Naphazoline hydrochloride
550-99-2
 US $20.00-1.00 / kg 1kg 0.99 30 tons Hebei Yanxi Chemical Co., Ltd.

Naphazoline hydrochloride Spectrum

Naphazoline hydrochloride(550-99-2)MSNaphazoline hydrochloride(550-99-2)1HNMRNaphazoline hydrochloride(550-99-2)13CNMRNaphazoline hydrochloride(550-99-2)IR1Naphazoline hydrochloride(550-99-2)IR2Naphazoline hydrochloride(550-99-2)Raman

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