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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE structure

CAS No.: 25371-96-4

Chemical Name:: 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Synonyms: TRIM;I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE;1-(2-Trifluoromethylphenyl)imidazole, 98+%;1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%;2-chloro-3-(dodecylamino)naphthalene-1,4-dione;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%;1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE

CBNumber:: CB1457890

Molecular Formula:: C10H7F3N2

Molecular Weight:: 212.17

MDL Number:: MFCD00041206

MOL File:: 25371-96-4.mol

Last updated:2024-11-17 08:48:38

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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Properties

Melting point	43 °C
Boiling point	75°C 0,02mm
Density	1.3253 (estimate)
Flash point	75°C/0.025mm
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
form	White solid.
pka	4.96±0.10(Predicted)
color	White
Sensitive	Light Sensitive
BRN	3955637
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference	25371-96-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HazardClass

IRRITANT, LIGHT SENSITIVE

HS Code

29339900

NFPA 704

	1
2		0

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T7313	1-[2-(Trifluoromethyl)phenyl]imidazole	25371-96-4	100mg	$165	2024-03-01	Buy
TCI Chemical	T2982	1-[2-(Trifluoromethyl)phenyl]imidazole min. 98.0 %	25371-96-4	200MG	$85	2024-03-01	Buy
TCI Chemical	T2982	1-[2-(Trifluoromethyl)phenyl]imidazole >98.0%(GC)	25371-96-4	1g	$254	2024-03-01	Buy
Cayman Chemical	81310	TRIM ≥98%	25371-96-4	50mg	$33	2024-03-01	Buy
Cayman Chemical	81310	TRIM ≥98%	25371-96-4	100mg	$62	2024-03-01	Buy

Product number	Packaging	Price	Buy
T7313	100mg	$165	Buy
T2982	200MG	$85	Buy
T2982	1g	$254	Buy
81310	50mg	$33	Buy
81310	100mg	$62	Buy

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Chemical Properties,Uses,Production

Description

TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2

Uses

TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.

Definition

ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

References

1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11598	64
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32343	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69

Supplier	Advantage
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Mainchem Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69

View Lastest Price from 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-16	TRIM 25371-96-4	US $33.00-68.00 / mg		98.98%	10g	TargetMol Chemicals Inc.
	2020-01-09	1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 25371-96-4	US $1.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

TRIM
25371-96-4
US $33.00-68.00 / mg
98.98%
TargetMol Chemicals Inc.

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
25371-96-4
US $1.00 / KG
99%
Career Henan Chemical Co

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I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE TRIM 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98% 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98% 1-(2-Trifluoromethylphenyl)imidazole, 98+% 2-(1H-Imidazol-1-yl)benzotrifluoride, 1-(1H-Imidazol-1-yl)-2-(trifluoromethyl)benzene 1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]- 2-chloro-3-(dodecylamino)naphthalene-1,4-dione nNOS,eNOS,Inhibitor,TRIM,inhibit,anxiolytic-like effects,NO Synthase,Nitric oxide synthases,iNOS,antidepressant,NOS 25371-96-4 Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Enzyme Nitric Oxide Synthase L to O BioChemical Biochemicals and Reagents Imidazol&Benzimidazole