ChemicalBook >> CAS DataBase List >>N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

CAS No.
249889-64-3
Chemical Name:
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
Synonyms
CS-1473;SB 334867;SB 334867A;SB334867 HCl;Zinc00008794;SB-334867 hydrochloride;SB 334867 hydrochloride NEW;SB 334867A; SB334867; SB 334867;N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride)
CBNumber:
CB1458943
Molecular Formula:
C17H13N5O2
Molecular Weight:
319.32
MDL Number:
MFCD06411602
MOL File:
249889-64-3.mol
MSDS File:
SDS
Last updated:2023-05-18 11:30:59

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Properties

Melting point >235°C (dec.)
storage temp. Desiccate at RT
solubility Dichloromethane (Slightly), DMSO (Slightly)
form Solid
color White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 1960 SB334867 ≥99%(HPLC) 249889-64-3 1 $96 2021-12-16 Buy
Tocris 1960 SB334867 ≥99%(HPLC) 249889-64-3 10 $203 2021-12-16 Buy
Tocris 1960 SB334867 ≥99%(HPLC) 249889-64-3 50 $852 2021-12-16 Buy
TRC S154655 SB334867 249889-64-3 100mg $1260 2021-12-16 Buy
American Custom Chemicals Corporation API0008815 N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA HYDROCHLORIDE 95.00% 249889-64-3 50MG $1381.33 2021-12-16 Buy
Product number Packaging Price Buy
1960 1 $96 Buy
1960 10 $203 Buy
1960 50 $852 Buy
S154655 100mg $1260 Buy
API0008815 50MG $1381.33 Buy

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Uses,Production

Uses

SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.

Definition

ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.

Biological Activity

Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .

References

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Spectrum

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA SB 334867 Zinc00008794 Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride) SB 334867 hydrochloride NEW SB334867 HCl SB-334867 hydrochloride CS-1473 SB 334867A SB 334867A; SB334867; SB 334867 Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, hydrochloride (1:1) 249889-64-3 C17H13N5O2 C17H13N5O2HCl Orexin receptor