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Isonicotinic acid

CAS No.
55-22-1
Chemical Name:
Isonicotinic acid
Synonyms
INA;4-PYRIDINECARBOXYLIC ACID;4-PICOLINIC ACID;PYRIDINE-4-CARBOXYLIC ACID;PYRIDINE-3-CARBOXYLIC ACID;Isonicotic acid;Isonicotinic;4-Carboxypyridine;NEF5;bidinjiausn
CBNumber:
CB1462924
Molecular Formula:
C6H5NO2
Molecular Weight:
123.11
MDL Number:
MFCD00006429
MOL File:
55-22-1.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:52

Isonicotinic acid Properties

Melting point ≥300 °C (lit.)
Boiling point 260 °C (15 mmHg)
Density 1,47g/cm
refractive index 1.5423 (estimate)
Flash point 260°C/15mm
storage temp. no restrictions.
solubility 6g/l
pka 4.96(at 25℃)
form powder
color yellow to tan
PH 3-4 (6g/l, H2O, 20℃)(saturated solution)
Water Solubility 5.2 g/L (20 ºC)
Merck 14,5187
BRN 109599
InChIKey TWBYWOBDOCUKOW-UHFFFAOYSA-N
CAS DataBase Reference 55-22-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII Y8SYN761TQ
NIST Chemistry Reference Isonicotinic acid(55-22-1)
EPA Substance Registry System Isonicotinic acid (55-22-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  NS1103000
TSCA  Yes
HS Code  29333999
Toxicity LD50 orally in Rabbit: 5000 mg/kg
NFPA 704
1
2 0

Isonicotinic acid price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I17508 Isonicotinic acid 99% 55-22-1 5g $27.6 2024-03-01 Buy
Sigma-Aldrich I17508 Isonicotinic acid 99% 55-22-1 100g $31.6 2024-03-01 Buy
Sigma-Aldrich 8.00736 4-Pyridinecarboxylic acid for synthesis 55-22-1 5G $34.2 2024-03-01 Buy
Sigma-Aldrich 8.00736 4-Pyridinecarboxylic acid for synthesis 55-22-1 250g $86.3 2024-03-01 Buy
TCI Chemical I0207 Isonicotinic Acid >99.0%(HPLC)(T) 55-22-1 25g $23 2024-03-01 Buy
Product number Packaging Price Buy
I17508 5g $27.6 Buy
I17508 100g $31.6 Buy
8.00736 5G $34.2 Buy
8.00736 250g $86.3 Buy
I0207 25g $23 Buy

Isonicotinic acid Chemical Properties,Uses,Production

Chemical Properties

isonicotinic acid is also known as pyridine-4-carboxylic acid. white to light yellow crystal powder or white needle crystals. odorless, sublimable. molecular weight 123.11. melting point 319°C . slightly soluble in cold water, soluble in hot water, insoluble in alcohol, benzene and ether. isonicotinic acid is an amphoteric compound that is soluble in both acids and bases. soluble in hot water and ethanol, slightly soluble in cold water and ether. stable to heat and oxidation.

Uses

Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) .
Isonicotinic acid is a moderately basic compound (based on its pKa). Isonicotinic acid is an organic compound with a carboxyl group on a pyridine ring. The carboxyl group for isonicotinic acid is on the 4-position instead of the 3-position for nicotinic acid. It is an isomer of nicotinic acid. Isonicotinic acid is a metabolite of isoniazid.
Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals.
Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines

Definition

ChEBI: Isonicotinic acid is a pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring. It has a role as a human metabolite and an algal metabolite. It is a conjugate acid of an isonicotinate.

Preparation

Isonicotinic acid is synthesized by continuous oxidation with 4-methylpyridine as raw material and vanadium pentoxide as catalyst. The purity of the industrial product isonicotinic acid is more than 95%, and the yield of the above method is 70-75%. The consumption of 4-methylpyridine per ton of product is 1070kg.

Application

Isonicotinic acid (IN) can be used as:
An organocatalyst in the one pot four component condensation reaction, to synthesize pyranopyrazoles based heterocyclic compounds.
An organic ligand for the preparation of copper(I) halide coordination polymer [CuBr(IN)]n, by hydrothermal method.
As a starting material for the synthesis of cation-dimers with potent antimalarial activity.

Purification Methods

Crystallise the acid repeatedly from water and dry it under vacuum at 110o or sublime it at 260o/15mm (m 319o). [Beilstein 22 III/IV 518, 22/2 V 188.]

108-89-4
55-22-1
Synthesis of Isonicotinic acid from 4-Methylpyridine
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View Lastest Price from Isonicotinic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isonicotinic acid pictures 2024-12-23 Isonicotinic acid
55-22-1
US $99.00-80.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Isonicotinic acid pictures 2024-12-20 Isonicotinic acid
55-22-1
US $6.00 / kg 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd
Isonicotinic acid  pictures 2024-12-19 Isonicotinic acid
55-22-1
US $6.00 / kg 1kg More than 99% 2000KG/Month Hebei Longbang Technology Co., Ltd
  • Isonicotinic acid pictures
  • Isonicotinic acid
    55-22-1
  • US $99.00-80.00 / kg
  • 99%
  • HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
4-PYRIDINECARBOXYLIC ACID FOR SYNTHESIS Isonicotinic aci 66 kDa neurofilament protein ANTI-INA (ALPHA INTERNEXIN) (CENTER) antibody produced in rabbit NEF5 Neurofilament 5 Pyridine-4-carboxylic acid, 4-Carboxypyridine Isonicotinic acid, CP,98% PYRIDINE-GAMMA-CARBOXYLIC ACID RARECHEM AL BO 0219 TIMTEC-BB SBB004278 Acide iso-nicotinique acideiso-nicotinique gamma-Picolinic acid AKOS B030576 ISONICOTINIC ACID Isonicotinic acid feed grade TOLFENAMIC ACID EPY(CRM STANDARD) Isonicotinicacid,99% 4-PYRIDINECARBOXYLICACID(ISO-NICOTINICACID) ISONICOTINIC ACID PYRIDINE-4-CARBOXYLIC ACID Pyridin-4-carbonobic acid 4-Carboxypyridin p-Pyridinecarboxylic 4-Pyridincarboxylic acid Isonicotinic acid,4-Picolinic acid, Pyridine-4-carboxylic acid 4-picolinate Isonicotinic acid, 99% 100GR Isonicotinic acid, 99% 500GR 4-Picolinic acid, Pyridine-4-carboxylic acid gamma-picolinicacid gamma-pyridinecarboxylicacid p-pyridinecarboxylicacid Pyridinecarboxylic acid-(4) Nicotinic EP Impurity E Nicotinic Acid EP Impurity E Isoniazid Impurity 2 4-Pcolinnic acid Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid bidinjiausn 4-pyridinecarboxylate IsonicotinicAcid> Pyridine-4-carboxylic Acid (Isonico Isonicotinic acid,AR,99% High purity Isonicotinic acid Nicotinic Acid EP Impurity E (Isonicotinic Acid) Nicotinic Acid Impurity 5 (Nicotinic Acid EP Impurity E) 55-22-1 isonicotinic Isonicotinic acid ISO 9001:2015 REACH isonicotinic acid,4-Pyridinecarboxylic acid best Isonicotinic acid Isoniazide impurity Isonicotinic Acid, ≥ 99.0% PYRIDINE-4-CARBOXYLIC ACID PYRIDINE-3-CARBOXYLIC ACID 4-Carboxypyridine 4-PYRIDINECARBOXYLIC ACID 4-PICOLINIC ACID