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TP0427736

TP0427736 structure

CAS No.: 864374-00-5

Chemical Name:: TP0427736

Synonyms: TP427736;TP-427736;TP0427736;TP0427736 HCl;Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-

CBNumber:: CB14667437

Molecular Formula:: C14H10N4S2

Molecular Weight:: 298.39

MDL Number:: MFCD32644807

MOL File:: 864374-00-5.mol

Last updated:2023-05-21 10:59:17

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TP0427736 Properties

Boiling point	634.7±65.0 °C(Predicted)
Density	1.439±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble
pka	9.70±0.10(Predicted)
Water Solubility	Water: Insoluble

TP0427736 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biorbyt Ltd	orb573383	TP0427736 HCl >98%	864374-00-5	100mg	$1060.8	2021-12-16	Buy
Biorbyt Ltd	orb573383	TP0427736 HCl >98%	864374-00-5	250mg	$2097.8	2021-12-16	Buy
Biorbyt Ltd	orb573383	TP0427736 HCl >98%	864374-00-5	1g	$4173.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
orb573383	100mg	$1060.8	Buy
orb573383	250mg	$2097.8	Buy
orb573383	1g	$4173.5	Buy

TP0427736 Chemical Properties,Uses,Production

Biological Activity

TP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM.

in vitro

TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2.

in vivo

TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen.

target

Target	Value
ALK5 (Cell-free assay)	2.72 nM

TP0427736 Preparation Products And Raw materials

Raw materials

Preparation Products

TP0427736 Suppliers

Global( 19)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3453	58
Guangzhou Tomums Life Science Co., Ltd.	020-31155029 18902330969	sales@tomums.cn	China	4698	58
BOC Sciences	--	info@bocsci.com	USA	0	65
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Absin Bioscience Inc.	021-38015121 15000105423	chenjw@absin.cn	China	24734	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Aladdin Scientific	58
Guangzhou Isun Pharmaceutical Co., Ltd	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Guangzhou Tomums Life Science Co., Ltd.	58
BOC Sciences	65
DC Chemicals	58
Absin Bioscience Inc.	58

864374-00-5(TP0427736)Related Search:

PTH-EPSILON-PHENYLTHIOCARBAMYL-DL-LYSINE

TP0427736 TP0427736 HCl TP427736 TP-427736 Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]- 864374-00-5