ChemicalBook >> CAS DataBase List >>Fmoc-Tyr(Me)-OH

Fmoc-Tyr(Me)-OH

Fmoc-Tyr(Me)-OH structure

CAS No.: 77128-72-4

Chemical Name:: Fmoc-Tyr(Me)-OH

Synonyms: Fmoc;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-PHE(4-OME)-OH;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH;Methoxy phenylalanine

CBNumber:: CB1468274

Molecular Formula:: C25H23NO5

Molecular Weight:: 417.45

MDL Number:: MFCD00153368

MOL File:: 77128-72-4.mol

Last updated:2023-10-23 12:43:00

Request For Quotation

Fmoc-Tyr(Me)-OH Properties

Melting point	161 °C
Boiling point	647.8±55.0 °C(Predicted)
Density	1.274±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
form	powder to crystal
pka	2.97±0.10(Predicted)
color	White to Almost white
InChIKey	JYQODLWFOPCSCS-QHCPKHFHSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	77128-72-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335-H315

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

WGK Germany

WGK 2 water endangering

HazardClass

IRRITANT

HS Code

29242990

NFPA 704

	1
0		0

Fmoc-Tyr(Me)-OH price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52056	Fmoc-Tyr(Me)-OH Novabiochem?	77128-72-4	5G	$121	2024-03-01	Buy
Sigma-Aldrich	CDS006940	Fmoc-Tyr(Me)-OH AldrichCPR	77128-72-4	10MG	$68.1	2023-06-20	Buy
Sigma-Aldrich	8.52056	Fmoc-Tyr(Me)-OH Novabiochem?	77128-72-4	1g	$35.3	2023-01-07	Buy
Alfa Aesar	H52117	N-Fmoc-4-methoxy-L-phenylalanine, 95%	77128-72-4	1g	$57.65	2024-03-01	Buy
Alfa Aesar	H52117	N-Fmoc-4-methoxy-L-phenylalanine, 95%	77128-72-4	5g	$246.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.52056	5G	$121	Buy
CDS006940	10MG	$68.1	Buy
8.52056	1g	$35.3	Buy
H52117	1g	$57.65	Buy
H52117	5g	$246.65	Buy

Fmoc-Tyr(Me)-OH Chemical Properties,Uses,Production

Description

Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

Chemical Properties

White to off-white powder

Synthesis

Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.

References

[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.

Fmoc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

Fmoc-Tyr(Me)-OH Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8617390183901	daisy@enlaibio.com	China	1106	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18779	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Fmoc-Tyr(Me)-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-22	Fmoc-L-Tyr(me) 77128-72-4	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
	2019-07-06	FMOC-TYR(ME)-OH 77128-72-4	US $1.00 / KG	1KG	99%	20kg	Career Henan Chemical Co

Fmoc-L-Tyr(me)
77128-72-4
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

FMOC-TYR(ME)-OH
77128-72-4
US $1.00 / KG
99%
Career Henan Chemical Co

77128-72-4(Fmoc-Tyr(Me)-OH)Related Search:

FMOC-TYR(BZL)-OH 98%,FMOC-TYR(BZL)-OH N-Fmoc-O-Phenyl-L-Tyrosine Fmoc-Tyr(Ac)-OH FMOC-L-4-Fluorophe Fmoc-L-4-Iodophenylalanine

(S)-N-FMOC-4-Chlorophenylalanine FMOC-L-9-ANTHRYLALANINE FMOC-D, L-PHE(4-C(O)NH2) FMOC-L-4-Methylphe Fmoc-4-nitro-L-phenylalanine

(S)-N-Fmoc-Allylglycine FMOC-L-4-CYANOPHENYLALANINE FMOC-TYR(ET)-OH FMOC-TYR(ALL)-OH,FMOC-TYR(AL)-OH FMOC-TYR(2-BR-Z)-OH

FMOC-TYR(MALONYL-DI-OTBU)-OH Fmoc-Tyr(tBu)-OH Fmoc-Tyr(Me)-OH

1of4

Fmoc-4-Methoxy-L-Phe-OH Methoxy phenylalanine N-FMoc-4-Methoxy-L-phenylalanine, 95% FMoc-Tyr(Me)-OH FMoc-O-Methyl-L-tyrosine FMOC-(S)-b-(p-Methoxyphenyl)alanine (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid N-Fmoc-O-methyl-L-tyrosine, >=99% Fmoc-4-Methoxy-Phe N-ALPHA-FMOC-O-METHYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHYL-L-TYROSINE N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine Fmoc-O-methyl-L-tyrosine≥ 99% (HPLC) Fmoc-Tyr(Me)-OH Novabiochem N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHY-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-METHOXY-L-PHENYLALANINE (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(4-METHOXY-PHENYL)-PROPIONIC ACID FMOC-4-METHOXY-PHE-OH FMOC-4-METHOXY-L-PHENYLALANINE FMOC-4-METHOXYPHENYLALANINE FMOC-L-4-METHOXYPHE FMOC-TYR(ME)-OH FMOC-L-TYR(ME) FMOC-L-TYR(ME)-OH FMOC-L-TYROSINE(METHYL ETHER) FMOC-P-METHOXY-PHE-OH FMOC-PHE(4-OME)-OH FMOC-O-METHYL-L-TYROSINE FMOC-4-METHOXYPHENYLALANINE MIN 99% Fmoc-L-4-MeO-Phe-OH FMOC-TYR(AL)-OH (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(Me)-OH (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid Fmoc-Tyr(Me)-OH(Fmoc-4-Methoxy-Phe) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine> Fmoc-Tyr(Me)-OH (N-Fmoc-O-methyl-L-tyrosine) L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl- N-Fmoc-4-methoxy-L-phenylalanine,95% N-Fmoc-O-methyl-L-tyrosine N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-L-phenylalanine FMOC-TYR(ME)-OH USP/EP/BP Fmoc 77128-72-4 Phenylalanine [Phe, F] Unusual Amino Acids Amino Acids Fmoc-Amino acid series