3D-(6-ACYL) PHAD
- CAS No.
- 252042-59-4
- Chemical Name:
- 3D-(6-ACYL) PHAD
- Synonyms
- 3D-PHAD,3D-MPL;3D-(6-ACYL) PHAD;D-Glucose, 2-deoxy-6-O-[2-deoxy-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-;(2R,3S,4R,5R,6R)-2-(hydroxymethyl)-3-phosphonooxy-5-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]-6-[(2R,3S,4R,5R)-2,3,4-trihydroxy-6-oxo-5-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]hexoxy]oxan-4-yl] (3R)-3-tetradecanoyloxytetra decanoate
- CBNumber:
- CB14742596
- Molecular Formula:
- C96H181N2O21P
- Molecular Weight:
- 1730.47
- MDL Number:
- MOL File:
- 252042-59-4.mol
Density | 1.08±0.1 g/cm3(Predicted) |
---|---|
pka | 1.83±0.10(Predicted) |
FDA UNII | 5A35GQS15R |
3D-(6-ACYL) PHAD Chemical Properties,Uses,Production
Uses
3D-(6-acyl) PHAD? has been used:
- as a synthetic adjuvant in human papillomavirus (HPV) and virus-like particles (VLPs)-based HPV vaccine preparations
- as a component of liposomes for immunizing mice with P. falciparum (Pfs25) malaria transmission-blocking vaccine antigen candidate
- in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice
General Description
Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD?), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.
3D-(6-ACYL) PHAD Preparation Products And Raw materials
Raw materials
Preparation Products
3D-(6-ACYL) PHAD Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Shanghai AECOM Biotechnology Co. , Ltd. | 021-021-20956531 18116226605 | sui@neosunpharm.com | China | 350 | 55 |
Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | 495745175@qq.com | China | 7313 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
Shanghai Easy CDMO Co.,Ltd | 021-61734564 | August@easycdmo.com | China | 10010 | 58 |