EW-7197 Hydrochloride
- CAS No.
- 1352610-25-3
- Chemical Name:
- EW-7197 Hydrochloride
- Synonyms
- Vactosertib HCl;EW-7197 Hydrochloride;TEW-7197 Hydrochloride;Vactosertib Hydrochloride;Vactosertib (EW-7197) Hydrochloride;VactosertibHydrochloride/EW-7197Hydrochloride;N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline hydrochloride
- CBNumber:
- CB14796650
- Molecular Formula:
- C22H19ClFN7
- Molecular Weight:
- 435.89
- MDL Number:
- MFCD31619301
- MOL File:
- 1352610-25-3.mol
EW-7197 Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0040677 | Vactosertib(Hydrochloride) 98.57% | 1352610-25-3 | 2mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0040677 | Vactosertib(Hydrochloride) 98.57% | 1352610-25-3 | 5mg | $130 | 2021-12-16 | Buy |
| ChemScene | CS-0040677 | Vactosertib(Hydrochloride) 98.57% | 1352610-25-3 | 10mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-0040677 | Vactosertib(Hydrochloride) 98.57% | 1352610-25-3 | 25mg | $490 | 2021-12-16 | Buy |
| ChemScene | CS-0040677 | Vactosertib(Hydrochloride) 98.57% | 1352610-25-3 | 50mg | $816 | 2021-12-16 | Buy |
EW-7197 Hydrochloride Chemical Properties,Uses,Production
Description
Vactosertib, also known as TEW-7197 is a potent ALK5 inhibitor. TEW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung.EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mic
in vivo
EW-7197 treatment ameliorates acquired lymphedema in a mouse tail model by increasing lymphangiogenesis and interstitial flow of the lymphatics by inhibition of the fibrosis. The differences in maximal tail thicknesses between the control and treatment groups were statistically significant from 2 to 4 weeks after surgery. The treatment group showed a greater number of lymphatic vessels at the surgery site than the control group. The treatment group also showed more FITC coverage area at the surgery site._x000D_ _x000D_ Reference: Lymphat Res Biol. 2020 Oct;18(5):433-438. https://pubmed.ncbi.nlm.nih.gov/32105567/
target
Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM.
EW-7197 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
EW-7197 Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29785 | 68 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1991 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9356 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | sales@ubiochem.com | China | 4297 | 58 |
View Lastest Price from EW-7197 Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Vactosertib Hydrochloride
1352610-25-3
|
US $78.00-102.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Vactosertib Hydrochloride
1352610-25-3
- US $78.00-102.00 / mg
- TargetMol Chemicals Inc.