HS1371
- CAS No.
- 2158197-70-5
- Chemical Name:
- HS1371
- Synonyms
- HS1371;CS-2831;HS-1371, 10 mM in DMSO;HS-1371; HS 1371; HS1371;2158197-70-5;7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline;Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371
- CBNumber:
- CB14800382
- Molecular Formula:
- C24H24N4O
- Molecular Weight:
- 384.47
- MDL Number:
- MFCD31813738
- MOL File:
- 2158197-70-5.mol
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
|---|---|
| solubility |
DMF:30.0(Max Conc. mg/mL);78.03(Max Conc. mM) DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.52(Max Conc. mM) DMSO:11.56(Max Conc. mg/mL);30.06(Max Conc. mM) Ethanol:4.5(Max Conc. mg/mL);11.7(Max Conc. mM) |
| form | A solid |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
HS1371 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb573183 | HS-1371 >98% | 2158197-70-5 | 100mg | $1060.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573183 | HS-1371 >98% | 2158197-70-5 | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573183 | HS-1371 >98% | 2158197-70-5 | 1g | $3580.2 | 2021-12-16 | Buy |
| Ambeed | A982329 | HS1371 97% | 2158197-70-5 | 5mg | $106 | 2021-12-16 | Buy |
| Ambeed | A982329 | HS1371 97% | 2158197-70-5 | 10mg | $169 | 2021-12-16 | Buy |
HS1371 Chemical Properties,Uses,Production
Uses
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1].
Biological Activity
HS1371 is a potent RIP3 kinase inhibitor with IC50 of 20.8 nM. It binds to the ATP-binding region of RIP3, thereby preventing ATP binding, inhibiting the enzymatic activity of RIP3 in vitro.
in vitro
HS1371 inhibits autorenal phosphorylation of RIP3 at S227. In HT-29 cells, it has full inhibitory activity on TNF-induced necroptosis signaling and is inactive on the phosphorylation of RIP3 and MLKL. It protects cells from RIP3-dependent necrotic cell death but does not affect apoptotic cell death.
target
| Target | Value |
| RIP3 kinase () | 20.8 nM |
References
[1] Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125. DOI:10.1038/s12276-018-0152-8
HS1371 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
