Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine

rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine

rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Structure
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine structure
CAS No.
1225383-33-4
Chemical Name:
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
Synonyms
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine;L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-;Ligands for E3 Ligase,E3 ligase Ligand 8,Inhibitor,inhibit,E3 ligase-recruiting Moiety,E-3 ligase Ligand 8;(S)-2-((2S,3R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid;(2S)-2-[(2S,3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
CBNumber:
CB14888973
Molecular Formula:
C31H34N2O6
Molecular Weight:
530.61
MDL Number:
MFCD32197317
MOL File:
1225383-33-4.mol
Last updated:2025-04-18 09:51:41
Request For Quotation

rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Properties

Boiling point 815.8±65.0 °C(Predicted)
Density 1.252±0.06 g/cm3(Predicted)
pka 3.37±0.10(Predicted)
form Solid
color White to off-white

rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Chemical Properties,Uses,Production

Uses

E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

IC 50

IAP

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6576 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12306 58
Shanghai ruichang pharmaceutical technology co., LTD 18621054990 maychemicals@sina.com China 673 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1591 58
Wuhan Anruike Pharmaceutical Technology Co., Ltd. 18572841024 28128719@qq.com China 1985 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29774 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Daicel Chiral Technologies (China)CO.,LTD 65
Shanghai EFE Biological Technology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Shanghai ruichang pharmaceutical technology co., LTD 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Wuhan Anruike Pharmaceutical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Lastest Price from rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
E3 ligase Ligand 8 pictures 2024-11-19 E3 ligase Ligand 8
1225383-33-4
 US $29.00-95.00 / mg 98.86% 10g TargetMol Chemicals Inc.

1225383-33-4(rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine)Related Search:

E3 ligase Ligand 18 E3 ligase Ligand 10 L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- E3 ligase Ligand 14
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]- Ligands for E3 Ligase,E3 ligase Ligand 8,Inhibitor,inhibit,E3 ligase-recruiting Moiety,E-3 ligase Ligand 8 (S)-2-((2S,3R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid (2S)-2-[(2S,3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid 1225383-33-4