ChemicalBook >> CAS DataBase List >>CHF-5022
CHF-5022
- CAS No.
- 749269-77-0
- Chemical Name:
- CHF-5022
- Synonyms
- CHF-5022;CHEMBL196246;UNII-JO8EVV007Q;Cyclopropanecarboxylic acid, 1-[2-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-
- CBNumber:
- CB14919701
- Molecular Formula:
- C17H12F4O2
- Molecular Weight:
- 324.27
- MDL Number:
- MOL File:
- 749269-77-0.mol
Last updated:2025-04-18 09:51:41
| Boiling point | 405.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.403±0.06 g/cm3(Predicted) |
| pka | 3.29±0.20(Predicted) |
| FDA UNII | JO8EVV007Q |
CHF-5022 Chemical Properties,Uses,Production
Uses
CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (?22.2±4.8% at 100 μM)[1].
in vivo
After multiple oral administration, CHF5022 is absorbed dose-dependently, with a fair penetration of the brain (≈10%) of young Tg2575 mice[1].
References
[1] Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55(4):318-28. DOI:10.1016/j.phrs.2006.12.010
CHF-5022 Preparation Products And Raw materials
Raw materials
Preparation Products
CHF-5022 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| BOC Sciences | 65 |
CHF-5022
CHEMBL196246
UNII-JO8EVV007Q
Cyclopropanecarboxylic acid, 1-[2-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-
749269-77-0