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1,2-Benzisothiazol-3(2H)-one

1,2-Benzisothiazol-3(2H)-one Structure
1,2-Benzisothiazol-3(2H)-one structure
CAS No.
2634-33-5
Chemical Name:
1,2-Benzisothiazol-3(2H)-one
Synonyms
BIT;1,2-BENZISOTHIAZOLIN-3-ONE;BENZISOTHIAZOLINONE;BIT-85;Benzo[d]isothiazol-3(2H)-one;BENZISOTHIAZOLONE;proxel;1,2-Benzisothiazolin;Benzisothiazolin-3-on (BIT);1,2-benzisothiazoline-3-one
CBNumber:
CB1496512
Molecular Formula:
C7H5NOS
Molecular Weight:
151.19
MDL Number:
MFCD00044001
MOL File:
2634-33-5.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02
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1,2-Benzisothiazol-3(2H)-one Properties

Melting point 154-158 °C(lit.)
Boiling point 360°C (rough estimate)
Density 1.2170 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in dichloromethane, dimethyl sulfoxide, methanol.
pka 10.19±0.20(Predicted)
form Solid
color White to Light yellow to Light orange
biological source rabbit
Water Solubility 1.288g/L at 20℃
InChIKey DMSMPAJRVJJAGA-UHFFFAOYSA-N
LogP 0.7 at 20℃
CAS DataBase Reference 2634-33-5
Indirect Additives used in Food Contact Substances 1,2-BENZISOTHIAZOLIN-3-ONE
FDA 21 CFR 176.300; 177.2600
EWG's Food Scores 3-7
FDA UNII HRA0F1A4R3
EPA Substance Registry System 1,2-Benzisothiazolin-3-one (2634-33-5)
UNSPSC Code 41116107
NACRES NA.41

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H302-H315-H317-H318-H400
Precautionary statements  P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,N
Risk Statements  22-38-41-43-50
Safety Statements  24-26-37/39-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  DE4620000
HazardClass  9
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29339900
Hazardous Substances Data 2634-33-5(Hazardous Substances Data)
Toxicity LD50 oral in rat: 1020mg/kg
NFPA 704
1
2 0

1,2-Benzisothiazol-3(2H)-one price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB4502639 Anti-SIRP α1, C-Terminal antibody produced in rabbit affinity isolated antibody 100μG $506 2024-03-01 Buy
Sigma-Aldrich 561487 1,2-Benzisothiazol-3(2H)-one 97% 2634-33-5 5g $74.3 2024-03-01 Buy
Sigma-Aldrich 561487 1,2-Benzisothiazol-3(2H)-one 97% 2634-33-5 25g $216 2024-03-01 Buy
TCI Chemical B2430 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) 2634-33-5 25g $82 2024-03-01 Buy
TCI Chemical B2430 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) 2634-33-5 100g $239 2024-03-01 Buy
Product number Packaging Price Buy
SAB4502639 100μG $506 Buy
561487 5g $74.3 Buy
561487 25g $216 Buy
B2430 25g $82 Buy
B2430 100g $239 Buy

1,2-Benzisothiazol-3(2H)-one Chemical Properties,Uses,Production

Description

BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.

Chemical Properties

Yellow Powder

Uses

Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.

Uses

Antimicrobial agent.

Definition

ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

Application

1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.

General Description

1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.

Flammability and Explosibility

Not classified

Contact allergens

1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Toxicity evaluation

Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment.  BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.

Toxics Screening Level

The Initial Threshold Screening Level (ITSL) for 1,2-benzisothiazol-3(2H)-one of 0.1 μg/m3 with annual averaging time is being rescinded.

1,2-Benzisothiazol-3(2H)-one synthesis

2527-57-3
5697-20-1
2634-33-5
Synthesis of 1,2-Benzisothiazol-3(2H)-one from 2,2'-dithiobisbenzamide and 2-sulfanylbenzamide

1,2-Benzisothiazol-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-Chloro-1,2-benzisothiazole 3-(1-Piperazinyl)-1,2-benzisothiazole 2-(benzo[d]isothiazol-3-ylaMino)ethanol 3-(3-Oxo-1,2-benzisothiazol-2(3H)-yl)propanoic acid

1,2-Benzisothiazol-3(2H)-one Suppliers

Global( 623)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2957 58
Hubei Aumei New Material Co., Ltd.
+86-027-87366298 +8615927270571 tianyi@skbiology.cn China 282 58
WUXI HONOR SHINE CHEMICAL CO.,LTD
+86-0510-83593312 +8619805123561 sales@honorshinechem.com China 67 58
Hebei Anda Technology Co., LTD
+86-19831998802 106@hebeianda.cn China 278 58
Suzhou Genemill Biotechnology Co.,Ltd
+8615862502491 aimeegao@genemill.com China 39 58
Changzhou AniKare Pharmatech Co., Ltd.
+86-0519-8359-8696 +8618018249389 sales@anikare.com China 9875 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531157085 abby@chuanghaibio.com China 8808 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5868 58
Hebei Kingfiner Technology Development Co.Ltd 		+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3005 58
Shandong Juchuang Chemical Co., LTD 		+16837774622 admin@juchuangchem.com China 295 58
Supplier Advantage
Jinan Finer Chemical Co., Ltd 		58
Hubei Aumei New Material Co., Ltd.
58
WUXI HONOR SHINE CHEMICAL CO.,LTD
58
Hebei Anda Technology Co., LTD
58
Suzhou Genemill Biotechnology Co.,Ltd
58
Changzhou AniKare Pharmatech Co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Kingfiner Technology Development Co.Ltd 		58
Shandong Juchuang Chemical Co., LTD 		58

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  • Apr 22，2022

View Lastest Price from 1,2-Benzisothiazol-3(2H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2-Benzisothiazolin-3-one pictures 2025-04-23 1,2-Benzisothiazolin-3-one
2634-33-5
 US $10.00 / KG 1KG 99.5% 100 Hebei Chuanghai Biotechnology Co., Ltd
Benzisothiazolone pictures 2025-04-15 Benzisothiazolone
2634-33-5
 US $32.00 / kg 1kg 99% 5000kg/week Hebei Zhuanglai Chemical Trading Co.,Ltd
BIT pictures 2025-04-08 BIT
2634-33-5
 US $0.00-0.00 / kg 1kg ≥85% 500 tons Taicang Puyuan Pharmaceutical Co., Ltd.
  • BIT pictures
  • BIT
    2634-33-5
  • US $0.00-0.00 / kg
  • ≥85%
  • Taicang Puyuan Pharmaceutical Co., Ltd.

1,2-Benzisothiazol-3(2H)-one Spectrum

1,2-Benzisothiazol-3(2H)-one(2634-33-5)MS1,2-Benzisothiazol-3(2H)-one(2634-33-5)1HNMR1,2-Benzisothiazol-3(2H)-one(2634-33-5)13CNMR1,2-Benzisothiazol-3(2H)-one(2634-33-5)IR11,2-Benzisothiazol-3(2H)-one(2634-33-5)IR2

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1,2-Benzisothiazolin-3-One(MIT) 2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(7),8,10-trien-5-one 1,2-benzo-isothiazolin-3-ketone Acticide BIT Apizas AP-DS Bestcide 200K Bioban BIT 20DPG Canguard BIT Canguard BIT 20DPG Benzisothiazolin-3-one (BIT) Benzo[d]isothiazol-3(2H)-one, 98% 99% Benziothiazolinone solution Anti-SIRP α1, C-Terminal antibody produced in rabbit brain Ig-like molecule with tyrosine-based activation motifs inhibitory receptor SHPS-1 Macrophage fusion receptor 1,2-Benzisothiazol-3-ol Benzocil Proxel AB 1-Thia-2-azaindan-3-one 2,3-Dihydro-1,2-benzisothiazole-3-one Proxan Proxel XL proxil Benzisothiazolin-3-one 1,2-benzothiazol-3-one Benzo[d]Isothiazol-3-ol Benzoisothiazol-3-one 1,2-Benzisothiazol-3(2H)-one ,98% 1,2-Benzisothiazol-3(2H)-one [for BiocheMical Research] 2-Benzisothiazolin-3-one 1,2-Benzisothiazol-3(2H-)-one Benziothiazolinone solution,100ppm BIT-20 1,2-BENZISOTHAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3-ONE (BIT) 1,2-Benzisothiazoline-3(2H)-one 1,2-BENZISOTHIAZOL-3(2H)-ONE HYDRATE 1,2-BENZISOTHIAZOLIN-3-ONE (BIT) 98.5% 1,2-Benisothiazolin-3-One-2-Sodium Salt 1,2-Benzisothiazolin-3-One(Bit) 1,2-Bezisothiazolin-3-One(Bit) 1.2-Benzisothiazol-3(2H)-on 3-Hydroxy-1,2-benzisothiazole BIOCIDE--BIT 1,2-BENZISOTHLAZOLIN-3-ONE 1,2-BENZOISOTHIAZOLINE-3-ONE 1,2-BENZISOTHIAZOLINON-3-ONE PROXELHL 2-Hydrobenzo[d]isothiazol-3-one 1,2-benzisothiazol-3(2H)-one 1,2-benzisothiazolin-3-one 1,2-Benzisothiazol Benziothiazolinone Solution, 1000ppm 1,2-Benzisothiazoline-3-on 1,2-Benzisothiazolin-3-one BIT IN STOCK 2,3-dihydro-3-oxo-1,2-benzisothiazole BIT20/Proxel Gxl