SU 9516
- CAS No.
- 377090-84-1
- Chemical Name:
- SU 9516
- Synonyms
- CS-1784;SU 9516;SU-9516;SU 9516 USP/EP/BP;SU9516, 10 mM in DMSO;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-
- CBNumber:
- CB1497100
- Molecular Formula:
- C13H11N3O2
- Molecular Weight:
- 241.25
- MDL Number:
- MFCD05865243
- MOL File:
- 377090-84-1.mol
- MSDS File:
- SDS
| storage temp. | Store at +4°C |
|---|---|
| solubility | DMSO: ~17 mg/mL |
| form | crystalline |
| color | brown |
| FDA UNII | FD2SWT2SDI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SU 9516 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14796 | SU 9516 ≥98% | 377090-84-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14796 | SU 9516 ≥98% | 377090-84-1 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 14796 | SU 9516 ≥98% | 377090-84-1 | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 14796 | SU 9516 ≥98% | 377090-84-1 | 25mg | $305 | 2024-03-01 | Buy |
| TRC | S688045 | SU9516 | 377090-84-1 | 5mg | $235 | 2021-12-16 | Buy |
SU 9516 Chemical Properties,Uses,Production
Uses
SU 9516 is a 3-substituted indolinone CDK inhibitor with potent and selective inhibition towards cyclin-dependant kinases.
Definition
ChEBI: 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one is a member of indoles.
Biological Activity
Potent, selective cdk2 inhibitor (IC 50 values are 0.022, 0.04, >10, >10, 18 and >100 μ M for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G 1 and G 2 -M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro .
IC 50
CDK2: 22 nM (IC50); CDK1: 40 nM (IC50); CDK4: 200 nM (IC50); PDGFr: 18000 nM (IC50)
References
[1]. lane me, yu b, rice a, et al. a novel cdk2-selective inhibitor, su9516, induces apoptosis in colon carcinoma cells. cancer res, 2001, 61(16): 6170-6177.
[2]. yu b, lane me, wadler s. su9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight e2f complexes in human colon carcinoma cells. biochem pharmacol, 2002, 64(7): 1091-1100.
[3]. gao n, kramer l, rahmani m, et al. the three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3h-imidazol-4-yl)-meth-(z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (su9516) kills human leukemia cells via down-regulation of mcl-1 through a transcriptional mechanism. mol pharmacol, 2006, 70(2): 645-655.
SU 9516 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from SU 9516 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | SU9516
377090-84-1
|
US $30.00-67.00 / mg | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-24 | 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one
377090-84-1
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- SU9516
377090-84-1
- US $30.00-67.00 / mg
- 99.94%
- TargetMol Chemicals Inc.
-
- 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one
377090-84-1
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co