α-Pseudouridine
- CAS No.
- 10017-66-0
- Chemical Name:
- α-Pseudouridine
- Synonyms
- Pseudouridine B;α-Pseudouridine;α-Pseudouricdine;ALPHA-Pseudouridine;5-α-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione;5-(β-D-Ribofuranosyl)uracil from wheat bran;PSEUDOURIDINE NATURAL B ISOMER*FROM WHEAT BRAN;5-(α-D-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
- CBNumber:
- CB1504121
- Molecular Formula:
- C9H12N2O6
- Molecular Weight:
- 244.2
- MDL Number:
- MFCD00038458
- MOL File:
- 10017-66-0.mol
- MSDS File:
- SDS
α-Pseudouridine Chemical Properties,Uses,Production
Description
Alpha-pseudouridine is an unusual nucleoside with a "glycosidic" carbon-carbon bond.
Uses
Alpha-Pseudouridine is an isomer of Pseudouridine. It is a by-product of the chemical synthesis of beta-pseudouridine, is eliminated in EnginZyme’s enzymatic synthesis process. Pseudouridine is a fundamental component of RNA, found in all classes and species except the messenger (mRNA) variety. It most abundant RNA modification, found in all three phylogenic domains of life. When used in place of uridine in artificial mRNA, pseudouridine has proven to be critical to the success of mRNA vaccines (such as those for Covid-19) and future mRNA-based treatments.
References
[1] BARáT V, CHEN A, LIM Y H. An improved stereodivergent and practical synthesis of α- and β-pseudouridines?[J]. Reaction Chemistry & Engineering, 2022, 4: 798-803. DOI:10.1039/D2RE00381C.
[2] HAIQI XU. Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome[J]. Nature Methods, 2024, 21 11: 2024-2033. DOI:10.1038/s41592-024-02439-8.
[3] MARTIN HENGESBACH. Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET.[J]. RNA, 2010, 16 3: 610-620. DOI:10.1261/rna.1832510.
α-Pseudouridine Preparation Products And Raw materials
α-Pseudouridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3656 | 58 |
| Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9734 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Anhui Nature Pharmaceutical Co., Ltd. | 19155667820 | sales@nuoquanpharm.com | China | 142 | 58 |
| Shaanxi Didu New Material Co., Ltd | 029-81145920 15353716720 | 1046@dideu.com | China | 9990 | 58 |