ChemicalBook >> CAS DataBase List >>BAY 2416964
BAY 2416964
- CAS No.
- 2242464-44-2
- Chemical Name:
- BAY 2416964
- Synonyms
- BAY241696;AHR antagonist 3;BAY 2416964 USP/EP/BP;6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide;(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide;4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-
- CBNumber:
- CB15865784
- Molecular Formula:
- C18H18ClN5O3
- Molecular Weight:
- 387.82
- MDL Number:
- MFCD32693912
- MOL File:
- 2242464-44-2.mol
Last updated:2024-07-02 08:55:01
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
BAY 2416964 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0114330 | BAY2416964 99.59% | 2242464-44-2 | 5mg | $280 | 2021-12-16 | Buy |
| ChemScene | CS-0114330 | BAY2416964 99.59% | 2242464-44-2 | 10mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0114330 | BAY2416964 99.59% | 2242464-44-2 | 25mg | $670 | 2021-12-16 | Buy |
| ChemScene | CS-0114330 | BAY2416964 99.59% | 2242464-44-2 | 50mg | $1050 | 2021-12-16 | Buy |
| DC Chemicals | 020439 | BAY2416964 | 2242464-44-2 | 002 | $1200 | 2021-12-16 | Buy |
BAY 2416964 Chemical Properties,Uses,Production
Use
BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.
In vitro
BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression with IC50 of 4.30 nM in a human monocytic U937 cells.
In vivo
BAY 2416964 (Example 192) is dissolved in Ethanol/Solutol/Water (10/40/50) and given at 30 mg/kg, QD, p.o.. The efficacy is calculated based on tumor volume. BAY 2416964 (Example 192) is shown to have the potential for solid tumour treatment.
BAY 2416964 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 2416964 Suppliers
Global( 40)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Qingdao Marine Biomedical Research Institute Co., Ltd. | 0532-85906825 18366218597 | wizard.s.bzh@163.com | China | 25 | 58 |
AHR antagonist 3
(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide
4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-
6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide
BAY 2416964 USP/EP/BP
BAY241696
2242464-44-2