7-Azaindole
- CAS No.
- 271-63-6
- Chemical Name:
- 7-Azaindole
- Synonyms
- 1H-PYRROLO[2,3-B]PYRIDINE;NSC 67063;NSC 77951;7-azindole;7-AZAINDOLE;7-Azaindole99%;7-Dideazapurine;7-Azaindole,98%;7-AZAINDOLE 98%;7-Aza-7H-indole
- CBNumber:
- CB1664663
- Molecular Formula:
- C7H6N2
- Molecular Weight:
- 118.14
- MDL Number:
- MFCD00005606
- MOL File:
- 271-63-6.mol
- MSDS File:
- SDS
Melting point | 105-107 °C (lit.) |
---|---|
Boiling point | 270 °C (753.1004 mmHg) |
Density | 1.1151 (rough estimate) |
refractive index | 1.5500 (estimate) |
Flash point | 270°C |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform, Methanol |
pka | 7.69±0.20(Predicted) |
form | Powder |
color | White to off-white |
BRN | 109667 |
InChIKey | MVXVYAKCVDQRLW-UHFFFAOYSA-N |
CAS DataBase Reference | 271-63-6(CAS DataBase Reference) |
FDA UNII | QX4465NR9T |
NIST Chemistry Reference | 1H-Pyrrolo[2,3-b]pyridine(271-63-6) |
EPA Substance Registry System | 1H-Pyrrolo[2,3-b]pyridine (271-63-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36-41-37/38-22 | |||||||||
Safety Statements | 39-26-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | UY8710000 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29339990 | |||||||||
NFPA 704 |
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7-Azaindole price More Price(42)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A95502 | 7-Azaindole 98% | 271-63-6 | 1g | $47.8 | 2024-03-01 | Buy |
TCI Chemical | P1117 | 1H-Pyrrolo[2,3-b]pyridine >98.0%(GC)(T) | 271-63-6 | 5g | $27 | 2024-03-01 | Buy |
TCI Chemical | P1117 | 1H-Pyrrolo[2,3-b]pyridine >98.0%(GC)(T) | 271-63-6 | 25g | $126 | 2024-03-01 | Buy |
Alfa Aesar | L07983 | 7-Azaindole, 98% | 271-63-6 | 1g | $25.65 | 2024-03-01 | Buy |
Alfa Aesar | L07983 | 7-Azaindole, 98% | 271-63-6 | 5g | $66.65 | 2024-03-01 | Buy |
7-Azaindole Chemical Properties,Uses,Production
Chemical Properties
Brown-Cyrstalline Solid
Uses
7-Azaindole is imidazolinone derivatives as CGRP receptor antagonists used in the treatment.
A heterocyclic molecule that can be utilized as a pharmaceutical building block.
Starting material in a recent synthesis of azaserotonin.
Application
7-Azaindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate. It is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, p38 kinase inhibitors, thrombin inhibitors, etc.
Preparation
Synthesis of 7-azaindole: in a single-necked flask, add 2.0 g of 2-amino-3-methylpyridine and 2.5 g of N-Methylformanilide into 40 mL of dichloromethane, and add 3.15 g of PCl with stirring under an ice-water bath. After 4 hours of reaction, the reaction system was slowly poured into 40 mL of ammonia water, and the insoluble matter was removed by suction filtration. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, and evaporated to dryness to obtain 2.91 g of 7-azaindole as a pale yellow solid, with a yield of 70%.
Definition
ChEBI: 1H-pyrrolo[2,3-b]pyridine is a pyrrolopyridine.
Purification Methods
Recrystallise it repeatedly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the picrate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]
7-Azaindole Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 145 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
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View Lastest Price from 7-Azaindole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-23 | 7-Azaindole
271-63-6
|
US $2.00 / KG | 1KG | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
![]() |
2024-08-21 | 7-Azaindole
271-63-6
|
US $30.00 / kg | 1kg | 98% | 3000kg | hebei hongtan Biotechnology Co., Ltd | |
![]() |
2024-08-21 | 7-Azaindole
271-63-6
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Guanlang Biotechnology Co,.LTD |
-
- 7-Azaindole
271-63-6
- US $2.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 7-Azaindole
271-63-6
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- 7-Azaindole
271-63-6
- US $9.00 / KG
- 99.9
- Hebei Guanlang Biotechnology Co,.LTD