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ENDOMORPHIN-1

CAS No.
189388-22-5
Chemical Name:
ENDOMORPHIN-1
Synonyms
YPWF-NH2;ENDOMORPHIN-1;TYR-PRO-TRP-PHE-NH2;H-TYR-PRO-TRP-PHE-NH2;Endomorphin-1 Acetate Salt;Endomorphin 1, Endomorphin 1;ENDOMORPHIN-1 (HUMAN, BOVINE);L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide;L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-;(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide
CBNumber:
CB1684104
Molecular Formula:
C34H38N6O5
Molecular Weight:
610.7
MDL Number:
MFCD01321063
MOL File:
189388-22-5.mol
Last updated:2024-11-19 23:02:33

ENDOMORPHIN-1 Properties

Melting point 144-146℃
Boiling point 1052.8±65.0 °C(Predicted)
Density 1.343±0.06 g/cm3(Predicted)
RTECS SQ7316800
storage temp. −20°C
solubility ≥14.9 mg/mL in H2O; ≥30.55 mg/mL in DMSO; ≥47 mg/mL in EtOH
pka 9.86±0.15(Predicted)
form Solid
color White to off-white
Water Solubility Soluble in water
CAS DataBase Reference 189388-22-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

WGK Germany  3

ENDOMORPHIN-1 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J66775 Endomorphin-1 189388-22-5 5mg $80.4 2021-12-16 Buy
Alfa Aesar J66775 Endomorphin-1 189388-22-5 25mg $308 2021-12-16 Buy
Tocris 1055 Endomorphin-1 189388-22-5 5 $127 2021-12-16 Buy
Usbiological 448211 Endomorphin 1 189388-22-5 5mg $403 2021-12-16 Buy
Usbiological E2291-02 Endomorphin 1 189388-22-5 50ul $410 2021-12-16 Buy
Product number Packaging Price Buy
J66775 5mg $80.4 Buy
J66775 25mg $308 Buy
1055 5 $127 Buy
448211 5mg $403 Buy
E2291-02 50ul $410 Buy

ENDOMORPHIN-1 Chemical Properties,Uses,Production

Definition

ChEBI: L-Phenylalaninamide, L-tyrosyl-L-prolyl-L-tryptophyl- is an oligopeptide.

Biological Activity

endomorphins are two endogenous opioid peptides. endomorphin-1 (tyr-pro-trp-phe-nh2) and endomorphin-2 (tyr-pro-phe-phe-nh2) are tetrapeptides with the highest known affinity and specificity for the μ opioid receptor. endomorphin-1 is located in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors(1). it is assumed that endomorphins are the cleavage products of a larger precursor, but this polypeptide or protein has not yet been identified. perikarya expressing em2-like immunoreactivity were present in the posterior hypothalamus, whereas those expressing em1-like immunoreactivity were present in both the posterior hypothalamus and the nucleus of the solitary tract (nts). em1-like immunoreactivity was more widely and densely distributed throughout the brain than was em2-like immunoreactivity, whereas em2-like immunoreactivity was more prevalent in the spinal cord than was em1-like immunoreactivity. endomorphins participate in modulating nociceptive and autonomic nervous system processes and responsiveness to stress.figure1 formula of endomorphin-1figure 2 the endomorphin system and its evolving neurophysiological role

in vitro

Endomorphin 1 (EM-1) is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 2 (EM-2 ).

target

Ki: 20-30 nM (kappa 3 opioid receptor)

storage

-20°C (desiccate)

References

1. Greco, MA; Fuller, PM; Jhou, TC; Martin-Schild, S; Zadina, JE; Hu, Z; Shiromani, P; Lu, J (2008). "Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus". Brain Research 1245: 96–107.

ENDOMORPHIN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 116)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 904 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hangzhou Go Top Peptide Biotech
0571-88211921 sales1@gotopbio.com CHINA 2609 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58

View Lastest Price from ENDOMORPHIN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Endomorphin 1 pictures 2024-11-19 Endomorphin 1
189388-22-5
US $63.00-45.00 / mg 95.92% 10g TargetMol Chemicals Inc.
ENDOMORPHIN-1 pictures 2024-09-25 ENDOMORPHIN-1
189388-22-5
US $0.00 / gram 1gram 99% min 20 tons Wuhan Senwayer Century Chemical Co.,Ltd
ENDOMORPHIN-1 pictures 2020-02-14 ENDOMORPHIN-1
189388-22-5
US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
  • Endomorphin 1 pictures
  • Endomorphin 1
    189388-22-5
  • US $63.00-45.00 / mg
  • 95.92%
  • TargetMol Chemicals Inc.
  • ENDOMORPHIN-1 pictures
  • ENDOMORPHIN-1
    189388-22-5
  • US $0.00 / gram
  • 99% min
  • Wuhan Senwayer Century Chemical Co.,Ltd
  • ENDOMORPHIN-1 pictures
  • ENDOMORPHIN-1
    189388-22-5
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

ENDOMORPHIN-1 Spectrum

L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide H-TYR-PRO-TRP-PHE-NH2 ENDOMORPHIN-1 ENDOMORPHIN-1 (HUMAN, BOVINE) TYR-PRO-TRP-PHE-NH2 YPWF-NH2 L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl- (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide Endomorphin 1, Endomorphin 1 (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide Endomorphin-1 Acetate Salt 189388-22-5 C34H38N6O5 Biochemicals and Reagents BioChemical Amino Acids and Peptides Peptides Opioid Peptides Other Opioid Peptides SignalTransduction Other Opioid Peptides Other Opioid PeptidesPeptides for Cell Biology Opioid receptor and opioid-like receptor Peptide Neuropeptides Opioid Peptides