ANTI-53BP1
- CAS No.
- Chemical Name:
- ANTI-53BP1
- Synonyms
- P531;TP53B;TP53BP1;TRP53BP1;ANTI-P202;ANTI-53BP1;Anti-p53BP1;ANTI-TP53BP1;ANTI-53BP1 MOUSE MAB;MOUSE ANTI-HUMAN 53BP1
- CBNumber:
- CB1732018
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD04975126
- MOL File:
- Mol file
ANTI-53BP1 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | WH0007158M1 | Monoclonal Anti-TP53BP1 antibody produced in mouse clone 1B9, purified immunoglobulin, buffered aqueous solution | 100μg | $524 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB4503017 | Anti-53BP1 antibody produced in rabbit affinity isolated antibody | 100μG | $506 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB4503016 | Anti-53BP1 antibody produced in rabbit affinity isolated antibody | 100μG | $506 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA022133 | Anti-TP53BP1 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $580 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA008788 | Anti-TP53BP1 antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $580 | 2024-03-01 | Buy |
ANTI-53BP1 Chemical Properties,Uses,Production
Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .
General Description
TP53BP1 (tumor protein p53 binding protein 1) was initially recognized as a p53-binding protein, which increases the transcriptional activity of p53. It is also a tumor suppressor protein. This protein contains two BRCA1 domains in its C-terminal, called BRCA1 C-terminal (BRCT) domains. This protein is localized to the nucleus.
Biochem/physiol Actions
TP53BP1 (tumor protein p53 binding protein 1) plays an essential role in DNA damage repair and cell cycle control, where it interacts with damage sensors and signal transducers. It is involved in DSB (double strand break) repairs, and mediates microhomology-mediated end-joining (MMEJ) in G1-phase cells. In breast cancer, this protein acts as a tumor suppressor, and as a marker for the prognosis of breast cancer. It also inhibits angiogenesis in the same. Three variants of this gene are linked with reduced risk of basal cell carcinoma (BCC).
ANTI-53BP1 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-53BP1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| AntibodySystem | 18162686757 18162686757 | info@biolabreagent.com | China | 9818 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| AntibodySystem | 58 |