2-Bromothiazole
- CAS No.
- 3034-53-5
- Chemical Name:
- 2-Bromothiazole
- Synonyms
- 2-BROMO-1,3-THIAZOLE;CL028;TZ-Br;NSC 91532;2-Bromthiazol;2-bromo-thiazol;2-BROMOTHIAZOLE;2-BROMOTHIOAZOLE;Thiazole, 2-bromo-;2-THIAZOLYL BROMIDE
- CBNumber:
- CB1739860
- Molecular Formula:
- C3H2BrNS
- Molecular Weight:
- 164.02
- MDL Number:
- MFCD00005316
- MOL File:
- 3034-53-5.mol
- MSDS File:
- SDS
Melting point | 171 C |
---|---|
Boiling point | 171 °C (lit.) |
Density | 1.82 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | 146 °F |
storage temp. | 2-8°C |
solubility | Chloroform, Dichloromethane |
pka | 0.84±0.10(Predicted) |
form | Liquid |
color | Clear colorless to orange-brown |
Specific Gravity | 1.836 |
Water Solubility | insoluble |
BRN | 105724 |
InChIKey | RXNZFHIEDZEUQM-UHFFFAOYSA-N |
CAS DataBase Reference | 3034-53-5(CAS DataBase Reference) |
FDA UNII | 53KY5HU6FR |
NIST Chemistry Reference | Thiazole, 2-bromo-(3034-53-5) |
EPA Substance Registry System | Thiazole, 2-bromo- (3034-53-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H227-H315-H319-H335 | |||||||||
Precautionary statements | P210e-P261-P280a-P305+P351+P338-P405-P501a-P210-P280-P403+P235-P501 | |||||||||
Hazard Codes | Xi,F | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 23-24/25-36-26 | |||||||||
RIDADR | 1993 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT, FLAMMABLE | |||||||||
HS Code | 29341000 | |||||||||
NFPA 704 |
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2-Bromothiazole price More Price(42)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 160474 | 2-Bromothiazole 98% | 3034-53-5 | 5g | $54.9 | 2024-03-01 | Buy |
Sigma-Aldrich | 160474 | 2-Bromothiazole 98% | 3034-53-5 | 25g | $102 | 2024-03-01 | Buy |
TCI Chemical | B1280 | 2-Bromothiazole >98.0%(GC) | 3034-53-5 | 25g | $79 | 2024-03-01 | Buy |
TCI Chemical | B1280 | 2-Bromothiazole >98.0%(GC) | 3034-53-5 | 250g | $464 | 2024-03-01 | Buy |
Alfa Aesar | A14838 | 2-Bromothiazole, 99% | 3034-53-5 | 10g | $59.65 | 2024-03-01 | Buy |
2-Bromothiazole Chemical Properties,Uses,Production
Description
It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.1 Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.2, 3 In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.4 Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.5
Referrence
- Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
- Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
- Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
- Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
- Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.
Chemical Properties
Colourless Liquid
Uses
2-Bromothiazole, is intended used for research purpose only. It is also used as Aryl halide which are used to N-arylate 5- and 7-azaindoles. Copper-catalyzed cyanation provides 2-cyanothiazole
Uses
2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.
Uses
Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2
2-Bromothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3921 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 807 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
View Lastest Price from 2-Bromothiazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-07-22 | 2-Bromothiazole
3034-53-5
|
US $0.00-0.00 / kg | 1kg | 98% | 10ton | JINING XINHE CHEMICAL CO., LTD | |
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2024-07-18 | 2-Bromothiazole
3034-53-5
|
US $1.00 / Kg | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
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2024-04-22 | 2-Bromothiazole
3034-53-5
|
US $32.00-1.10 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 2-Bromothiazole
3034-53-5
- US $0.00-0.00 / kg
- 98%
- JINING XINHE CHEMICAL CO., LTD
-
- 2-Bromothiazole
3034-53-5
- US $1.00 / Kg
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Bromothiazole
3034-53-5
- US $32.00-1.10 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
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