ChemicalBook >> CAS DataBase List >>MRGPRX1 agonist 1
MRGPRX1 agonist 1
- CAS No.
- 2377379-39-8
- Chemical Name:
- MRGPRX1 agonist 1
- Synonyms
- BUN79398;MRGPRX1 agonist 1;MRGPRX1 agonist 1,Inhibitor,MRGPRX-1 agonist 1,inhibit;Benzenesulfonamide, N-[2-[(1-amino-6-isoquinolinyl)oxy]-4-methylphenyl]-2-methoxy-
- CBNumber:
- CB18054464
- Molecular Formula:
- C23H21N3O4S
- Molecular Weight:
- 435.5
- MDL Number:
- MFCD32263428
- MOL File:
- 2377379-39-8.mol
Last updated:2024-07-02 08:55:01
Boiling point | 642.0±65.0 °C(Predicted) |
---|---|
Density | 1.365±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO : 130 mg/mL (298.51 mM; Need ultrasonic) |
pka | 8.81±0.10(Predicted) |
form | Solid |
color | White to yellow |
InChI | InChI=1S/C23H21N3O4S/c1-15-7-10-19(26-31(27,28)22-6-4-3-5-20(22)29-2)21(13-15)30-17-8-9-18-16(14-17)11-12-25-23(18)24/h3-14,26H,1-2H3,(H2,24,25) |
InChIKey | BWEJNHRMGZUMNU-UHFFFAOYSA-N |
SMILES | C1(S(NC2=CC=C(C)C=C2OC2C=CC3=C(C=2)C=CN=C3N)(=O)=O)=CC=CC=C1OC |
MRGPRX1 agonist 1 Chemical Properties,Uses,Production
Biological Activity
MRGPRX1 agonist 1 is a highly potent agonist of MRGPRX1 (Mas-related G-protein-coupled receptor X1), with an EC50 of 50 nM, and is inactive on MRGPRC11. Analgesic effect[1].
References
[1]. Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62(18):8631-8641.
MRGPRX1 agonist 1 Preparation Products And Raw materials
Raw materials
Preparation Products
MRGPRX1 agonist 1 Suppliers
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MRGPRX1 agonist 1
MRGPRX1 agonist 1,Inhibitor,MRGPRX-1 agonist 1,inhibit
Benzenesulfonamide, N-[2-[(1-amino-6-isoquinolinyl)oxy]-4-methylphenyl]-2-methoxy-
BUN79398
2377379-39-8