Pomalidomide-NH-PEG3-azide
- CAS No.
- 2271036-46-3
- Chemical Name:
- Pomalidomide-NH-PEG3-azide
- Synonyms
- IUN-36463;Pomalidomide-NH-PEG3-azide;Pomalidomide 4'-PEG3-azide;4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- CBNumber:
- CB18363902
- Molecular Formula:
- C21H26N6O7
- Molecular Weight:
- 474.47
- MDL Number:
- MFCD32903293
- MOL File:
- 2271036-46-3.mol
Pomalidomide-NH-PEG3-azide Chemical Properties,Uses,Production
Uses
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Cereblon
storage
Store at -20°C
References
[1] Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2
Pomalidomide-NH-PEG3-azide Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-NH-PEG3-azide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13482353728 | sales@fdc-chemical.com | China | 15538 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4838 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1592 | 58 |
| Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD | 025-86755008 17751752005 | hszhang@bestfluorodrug.com | China | 2358 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 55017 | 58 |
| Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9857 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7995 | 58 |
| Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 6923 | 58 |
View Lastest Price from Pomalidomide-NH-PEG3-azide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-02 | Pomalidomide-NH-PEG3-azide
2271036-46-3
|
US $0.00 / mg | 100mg | >98.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
-
- Pomalidomide-NH-PEG3-azide
2271036-46-3
- US $0.00 / mg
- >98.00%
- Xian confluore Biological Technology Co., Ltd.