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U-77891

U-77891 Structure
U-77891 structure
CAS No.
119878-31-8
Chemical Name:
U-77891
Synonyms
U-77891;trans-3,4-Dibromo-N-methyl-N-(1-methyl-1-azaspiro[4.5]dec-6-yl)-benzamide;Benzamide, 3,4-dibromo-N-methyl-N-[(5R,6S)-1-methyl-1-azaspiro[4.5]dec-6-yl]-, rel-
CBNumber:
CB18430491
Molecular Formula:
C18H24Br2N2O
Molecular Weight:
444.2
MDL Number:
MOL File:
119878-31-8.mol
Last updated:2024-03-26 14:13:49
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U-77891 Properties

Boiling point 522.7±50.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
pka 9.72±0.40(Predicted)
FDA UNII 7P6974D7RX

U-77891 Chemical Properties,Uses,Production

Description

U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company.[1] It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700. This would help elucidate the relative positions of the hydrogen-bond acceptors and substituted aromatic system to find the compound with the lowest Ki value in a series of benzamide opioids dating back to the 1970s.[2] The original work found a mixture of agonists and antagonists.
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Uses

trans-3,4-Dibromo-N-methyl-N-(1-methyl-1-azaspiro[4.5]dec-6-yl)-benzamide is a μ-opioid, δ-opioid and κ-opioid receptors agonist and an analgesic agent.

U-77891 Preparation Products And Raw materials

Raw materials

Preparation Products

U-77891 Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Dorne Chemical Technology co. LTD 		+86-86-13583358881 +8618560316533 Ethan@dornechem.com China 3128 58
Supplier Advantage
Dorne Chemical Technology co. LTD 		58

View Lastest Price from U-77891 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Benzamide, 3,4-dibromo-N-methyl-N-[(5R,6S)-1-methyl-1-azaspiro[4.5]dec-6-yl]-, rel- pictures 2024-10-02 Benzamide, 3,4-dibromo-N-methyl-N-[(5R,6S)-1-methyl-1-azaspiro[4.5]dec-6-yl]-, rel-
119878-31-8
 US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
U-77891 pictures 2024-07-06 U-77891
119878-31-8
 US $0.00 / kg 1kg 0.99 10T Shandong Hanjiang Chemical Co., Ltd
  • U-77891 pictures
  • U-77891
    119878-31-8
  • US $0.00 / kg
  • 0.99
  • Shandong Hanjiang Chemical Co., Ltd
Benzamide, 3,4-dibromo-N-methyl-N-[(5R,6S)-1-methyl-1-azaspiro[4.5]dec-6-yl]-, rel- trans-3,4-Dibromo-N-methyl-N-(1-methyl-1-azaspiro[4.5]dec-6-yl)-benzamide U-77891 119878-31-8 C18H24Br2N2O