2-Chloro-1-propanol
- CAS No.
- 78-89-7
- Chemical Name:
- 2-Chloro-1-propanol
- Synonyms
- VPM-4G;Nsc122672;2-Chloropropanol;2-chloro-1-propano;MONOCHLOROPROPANOL;2-Chloro-1-propanol;2-chloropropan-1-ol;2-chloro-propan-1-ol;PROPYLENECHLORHYDRIN;2-chloropropylalcohol
- CBNumber:
- CB1851586
- Molecular Formula:
- C3H7ClO
- Molecular Weight:
- 94.54
- MDL Number:
- MFCD01941467
- MOL File:
- 78-89-7.mol
| Melting point | <25 °C |
|---|---|
| Boiling point | bp 133-134° |
| Density | d20 1.103 |
| refractive index | nD20 1.4362 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Sparingly) |
| form | Oil |
| pka | 14.16±0.10(Predicted) |
| color | Colourless |
| Odor | pleasant odor |
| Exposure limits | No exposure limit is set. However, on the basis of its similar toxic properties to ethylene chlorohydrin, a TLV-TWA air 10 ppm (approximately 40 mg/m3) is recommended. |
| LogP | 0.268 (est) |
| Substances Added to Food (formerly EAFUS) | PROPYLENE CHLOROHYDRIN |
| CAS DataBase Reference | 78-89-7 |
| EWG's Food Scores | 1 |
| FDA UNII | W3398732C7 |
| EPA Substance Registry System | 2-Chloro-1-propanol (78-89-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H312-H319-H302-H226 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312 | |||||||||
| RIDADR | 2611 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Hazardous Substances Data | 78-89-7(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 0.22 ml/kg; by skin penetration in rabbits: 0.48 ml/kg, Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969) | |||||||||
| NFPA 704 |
|
2-Chloro-1-propanol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FC146292 | 2-Chloro-1-propanol | 78-89-7 | 100mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146292 | 2-Chloro-1-propanol | 78-89-7 | 250mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146292 | 2-Chloro-1-propanol | 78-89-7 | 500mg | $400 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0199099 | 2-CHLORO-1-PROPANOL 95.00% | 78-89-7 | 5MG | $496.2 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146292 | 2-Chloro-1-propanol | 78-89-7 | 1g | $600 | 2021-12-16 | Buy |
2-Chloro-1-propanol Chemical Properties,Uses,Production
Chemical Properties
Propylene chlorohydrin is a colorless liquid.
Chemical Properties
Colorless liquid; mild, nonresidual odor. Soluble in water and alcohol.
Uses
In preparation of propylene oxide, q.v.
Uses
2-Chloropropanol is used as a solvent in the composition and method for removing a coating from a surface. 2-Chloropropanol is used as an organic solvent in liquid cleaner for the removal of post-etch residues from microsprocessors.
Uses
Propylene β-chlorohydrin is used in the pro duction of propylene oxide.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 4353, 1950 DOI: 10.1021/ja01166a005
General Description
Clear colorless liquid with a pleasant odor.
Air & Water Reactions
Water soluble.
Reactivity Profile
2-Chloro-1-propanol may be sensitive to prolonged exposure to light. 2-Chloro-1-propanol can react with oxidizing agents. .
Hazard
Moderate fire risk. Toxic by ingestion and skin absorption. Liver damage. Questionable car- cinogen.
Health Hazard
Propylene β-chlorohydrin is a moderatelytoxic compound having irritant actions onthe skin and eyes. Instilling 2.2 mg of liquidcaused severe eye irritation in rabbits. It cancause poisoning via ingestion, inhalation, andskin absorption. Exposure to 500 ppm for4 hours was lethal to rats. The lethal dosein dogs by oral intake was 200 mg/kg. Thetarget organs are the CNS, gastrointestinalsystem, liver, and kidney.
LD50 value, skin (rabbits): 529 mg/kg
Studies conducted to determine increasedrisks of pancreatic and lymphopoietic can cer among workers in ethylene and propylene chlorohydrin production remained inconclu sive and have given inconsistent findings(Olsen et al. 1997).
Fire Hazard
2-Chloro-1-propanol is flammable.
Safety Profile
Poison by ingestion. Moderately toxic by inhalation and skin contact. A skin and severe eye irritant. Flammable liquid when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Cl-.
Potential Exposure
This material is used in organic synthesis; to make other chemicals.
Shipping
UN2611Propylene chlorohydrin, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid.
Incompatibilities
Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Alcohols are sensitive to light and oxi- dation. It is unstable in solution. It undergoes hydrolysis in aqueous buffers. Contact with alkali metals, nitrides, and strong reducing agents may form flammable and/or toxic gases. May react with anhydrides forming acids and esters, generating noticeable heat, and also with oxoacids and carboxylic acids to form esters plus water, but the heat of reaction in the latter case typically is low. May initiate the polymerization of isocyanates and epoxides.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Chloro-1-propanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12984 | 57 | |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13350 | 58 |
| XinYao(Shenzhen) Biological Technology Co., Ltd. | 0755-89880280 | 3004662104@qq.com | China | 1829 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | ORDERS@QCSRM.COM | China | 24342 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10001 | 58 |
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