3-Mercaptopropionic acid
- CAS No.
- 107-96-0
- Chemical Name:
- 3-Mercaptopropionic acid
- Synonyms
- 3-Mercaptopropanoic acid;3-MPA;3-mercaptopropionic;3-thiopropionicacid;3-Thiopropionic acid;Thiopropionic acid;3-mercapto-propionicaci;3-mercapto-propanoicaci;3-Sulfanylpropanoic acid;3-Mercaptopropionic acid ( MPA)
- CBNumber:
- CB1852730
- Molecular Formula:
- C3H6O2S
- Molecular Weight:
- 106.14
- MDL Number:
- MFCD00004897
- MOL File:
- 107-96-0.mol
- MSDS File:
- SDS
| Melting point | 15-18 °C (lit.) |
|---|---|
| Boiling point | 110-111 °C/15 mmHg (lit.) |
| Density | 1.218 g/mL at 25 °C (lit.) |
| vapor pressure | 0.04 mm Hg ( 20 °C) |
| FEMA | 4587 | 3-MERCAPTOPROPIONIC ACID |
| refractive index |
n |
| Flash point | 201 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Crystalline Powder, Crystals, and/or Chunks |
| pka | pK1:;pK2:10.84(SH) (25°C) |
| color | White |
| Specific Gravity | 1.218 |
| Odor | sulfurous roasted |
| PH | 2 (120g/l, H2O, 20℃) |
| explosive limit | 1.60%(V) |
| Odor Type | sulfurous |
| Viscosity | 7.9mm2/s |
| Water Solubility | soluble |
| Sensitive | Air Sensitive & Hygroscopic |
| JECFA Number | 1936 |
| BRN | 773807 |
| Stability | Air Sensitive, Hygroscopic |
| InChIKey | DKIDEFUBRARXTE-UHFFFAOYSA-N |
| LogP | -2.3 at 22℃ |
| Substances Added to Food (formerly EAFUS) | 3-MERCAPTOPROPIONIC ACID |
| CAS DataBase Reference | 107-96-0(CAS DataBase Reference) |
| FDA UNII | B03TJ3QU9M |
| NIST Chemistry Reference | 3-Thiolpropanoic acid(107-96-0) |
| EPA Substance Registry System | 3-Mercaptopropanoic acid (107-96-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H301-H314-H332 | |||||||||
| Precautionary statements | P234-P261-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-34-23/24/25 | |||||||||
| Safety Statements | 7-26-36/37/39-45 | |||||||||
| RIDADR | UN 2922 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | UF5270000 | |||||||||
| F | 10-13 | |||||||||
| Autoignition Temperature | 662 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309070 | |||||||||
| Toxicity | LD50 orally in Rabbit: 96 mg/kg | |||||||||
| NFPA 704 |
|
3-Mercaptopropionic acid price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5801 | 3-Mercaptopropionic acid ≥99% | 107-96-0 | 5g | $50.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.05967 | 3-Mercaptopropionic acid for synthesis | 107-96-0 | 100mL | $46.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.05967 | 3-Mercaptopropionic acid for synthesis | 107-96-0 | 250ML | $91.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 63768 | 3-Mercaptopropionic acid ≥99.0% (HPLC) | 107-96-0 | 25ml | $205 | 2024-03-01 | Buy |
| TCI Chemical | M0061 | 3-Mercaptopropionic Acid >98.0%(GC)(T) | 107-96-0 | 25g | $20 | 2024-03-01 | Buy |
3-Mercaptopropionic acid Chemical Properties,Uses,Production
Anti-cancer properties
3-Mercaptopropionic acid is a liquid, and doses between 30 and 60 mg/kg can be used for IP seizure induction throughout development. 3-mercaptopropionic acid (3-MPA) is a convulsant and potent GAD1 inhibitor, which could inhibit the migration and invasiveness of oral cancer cells. Considering that inhibition of GAD1 impaired GABA-mediated immunosuppression, 3-MPA was also demonstrated to synergize with ICB treatment to exert better anti-tumor efficacy. Such a combination strategy could benefit the treatment of cancer types with elevated GAD1 expression. Since 3-MPA has not been approved for clinical use, it is urgent to discover novel GAD1 inhibitors that are more applicable to future clinical studies.
Chemical Properties
clear colourless to yellowish liquid after melting
Uses
A compound suitable for amino acid analysis by means of OPA
Uses
3-Mercaptopropionic acid is widely used in food and beverage industries as a flavoring agent. It is used in the production of PVC stabilizers, which are used as chain transfer agents in polymerizations. It can be used as primary or secondary, color stabilizer in combination with phenolic antioxidant for polymers. It acts as a sulfide ion equivalent and is utilized in the preparation of diaryl sulfide from aryl iodide.
Definition
ChEBI: A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.
Application
3-Mercaptopropionic acid (3-MPA) is used to produce hydrophilic SAMs, which are terminated with carboxylic acids and can be further functionalized to introduce more complex end groups such as enzymes for biosensor applications. SAMs of 3-MPA are capped on ZnSe quantum dots for the electrochemical detection of dopamine. 3-MPA is used as a capping agent on CdTe quantum dot nanocrystals (QD NCs) for use as labeling materials in biomedical applications. It can also be used to modify the surface of iron oxide nanoparticles (Fe2O3) in the extraction and preconcentration of Al3+ and Cr3+ ions from different biological samples.
General Description
3-Mercaptopropionic acid (3-MPA) is used as a self-assembled monolayer (SAM) with a thiol and carboxylic groups. It has short carbon chains and is mainly used as a capping agent on a variety of nanoparticles.
Biological Activity
3-Mercaptopropionic acid is a blocking drug that causes an increase in sleep and a decrease in wakefulness. A related finding is that nipecotic acid also increases the time needed for isoflurane to induce loss of consciousness, whereas 3-mercaptopropionic acid decreases anesthesia induction time[1].
References
[1] Thakkar, M. and R. McCarley. “Neurochemistry of Sleep and Wakefulness: Histamine in the control of sleep–wakefulness.”Basic Neurochemistry (Eighth Edition) (2012).
3-Mercaptopropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Vcan Advanced Material Co., Ltd. | +86-17306299870 +86-18652789875 | vcanam@vcanam.com | China | 35 | 58 |
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1009 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6567 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Qingdao RENAS Polymer Material Co., Ltd. | +86-0532-86867058 +86-18562606086 | sales@qdrenas.com | China | 476 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
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View Lastest Price from 3-Mercaptopropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | 3-Mercaptopropionic acid
107-96-0
|
US $100.00-75.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-22 | Mercapto Propionic Acid
107-96-0
|
US $70.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-22 | 3-Mercaptopropionic acid
107-96-0
|
US $40.00 / kg | 1kg | 99% | 5000kg/Week | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- 3-Mercaptopropionic acid
107-96-0
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Mercapto Propionic Acid
107-96-0
- US $70.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 3-Mercaptopropionic acid
107-96-0
- US $40.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
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