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CU-76

CU-76 Structure
CU-76 structure
CAS No.
2400954-58-5
Chemical Name:
CU-76
Synonyms
CU-76;CU 76,CU76;methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate;1,3,5-Triazine-2-carboxylic acid, 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-, methyl ester
CBNumber:
CB18571015
Molecular Formula:
C11H8F2IN5O2
Molecular Weight:
407.11
MDL Number:
MOL File:
2400954-58-5.mol
Last updated:2023-06-30 15:45:59
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CU-76 Properties

Boiling point 512.4±60.0 °C(Predicted)
Density 1.978±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml
form A crystalline solid
pka 2.77±0.10(Predicted)

CU-76 Chemical Properties,Uses,Production

Biological Activity

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 0.24 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

storage

Store at -20°C

References

1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)

CU-76 Preparation Products And Raw materials

Raw materials

Preparation Products

CU-76 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5587 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
ChemeGen 中国 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CU-76 CU 76,CU76 1,3,5-Triazine-2-carboxylic acid, 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-, methyl ester methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate 2400954-58-5