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4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride

4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride structure

CAS No.: 17297-82-4

Chemical Name:: 4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride

Synonyms: Nsc169881;Pervetral;Oxypendyl dihydrochloride;Pervetral dihydrochloride;4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride;1-Piperazineethanol, 4-[3-(10H-pyrido[3,2-B][1,4]benzothiazin-10-yl)propyl]-, dihydrochloride

CBNumber:: CB1903948

Molecular Formula:: C20H28Cl2N4OS

Molecular Weight:: 443.43352

MDL Number:: MFCD01702623

MOL File:: 17297-82-4.mol

Last updated:2022-12-21 16:56:50

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4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Properties

Melting point	218-220°
CAS DataBase Reference	17297-82-4
FDA UNII	4U8JH1NN7O

SAFETY

Risk and Safety Statements

Toxicity	LD50 orl-rat: 1610 mg/kg 27ZQAG-,273,1972

4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Chemical Properties,Uses,Production

Originator

Pervetral, Homburg , W. Germany ,1962

Manufacturing Process

32 parts of 10-(γ-N-piperazinopropyl)-4-azaphenthiazine in 200 cc of butanol with 9 parts of ethylene chlorohydrin and 14 parts of finely powdered potash are heated for 4 hours under reflux while stirring vigorously. After cooling, extraction is carried out with dilute hydrochloric acid, the substance is finally washed with water and the combined hydrochloric acid aqueous phase is washed twice with ether. The base is then liberated with concentrated sodium hydroxide solution and taken up in chloroform. The chloroform solution is dried with potash and concentrated by evaporation. 26.4 parts of (10-γ-N-Bhydroxyethylpiperazino-N1-propyl)-4-azaphenthiazine are distilled over at 280°C to 300°C/6 mm. The dihydrochloride is obtained in isopropanol with isopropanolic hydrochloric acid. The product melts at 218°C to 220°C.

Therapeutic Function

Antiemetic

Safety Profile

A poison by intravenous, intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx, SOx, and Cl-.

4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Preparation Products And Raw materials

Raw materials

2-Chloroethanol

Preparation Products

4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HONEST JOY HOLDINGS LIMITED	--	sales@honestjoy.cn	United States	6702	54

Supplier	Advantage
HONEST JOY HOLDINGS LIMITED	54

4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride 1-Piperazineethanol, 4-[3-(10H-pyrido[3,2-B][1,4]benzothiazin-10-yl)propyl]-, dihydrochloride Nsc169881 Oxypendyl dihydrochloride Pervetral Pervetral dihydrochloride 17297-82-4