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SHP099 (hydrochloride)

SHP099 (hydrochloride) Structure
SHP099 (hydrochloride) structure
CAS No.
2200214-93-1
Chemical Name:
SHP099 (hydrochloride)
Synonyms
SHP099 hydrochloride, 10 mM in DMSO;SHP-099,SHP 099,SHP099 hydrochloride,Inhibitor,Phosphatase,inhibit,SHP-099 hydrochloride,SHP099
CBNumber:
CB19043898
Molecular Formula:
C16H20Cl3N5
Molecular Weight:
388.72
MDL Number:
MFCD30343849
MOL File:
2200214-93-1.mol
Last updated:2024-11-19 15:53:33
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SHP099 (hydrochloride) Properties

solubility DMSO:41.05(Max Conc. mg/mL);105.6(Max Conc. mM)
Methanol:25.0(Max Conc. mg/mL);64.31(Max Conc. mM)
Water:4.25(Max Conc. mg/mL);10.93(Max Conc. mM)
form Solid
color Yellow to orange

SHP099 (hydrochloride) Chemical Properties,Uses,Production

Description

SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). Because it is an oncoprotein associated with multiple cancer-related diseases, as well as a potential immunomodulator, controlling SHP2 activity is of significant therapeutic interest.

target

SHP2 inhibitor with IC50 =0.07 μM.

SHP099 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

SHP099 (hydrochloride) Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7312 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29764 68
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1992 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 yutianchun2007@126.com China 10003 58
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 sales@hasunny.com China 2380 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 973 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from SHP099 (hydrochloride) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SHP099 hydrochloride pictures 2024-11-19 SHP099 hydrochloride
2200214-93-1
 US $32.00-98.00 / mg 99.62% 10g TargetMol Chemicals Inc.

SHP099 (hydrochloride) Spectrum

SHP099 (hydrochloride)(2200214-93-1)1HNMR

2200214-93-1(SHP099 (hydrochloride))Related Search:

SHP099 SHP099 (hydrochloride)
SHP-099,SHP 099,SHP099 hydrochloride,Inhibitor,Phosphatase,inhibit,SHP-099 hydrochloride,SHP099 SHP099 hydrochloride, 10 mM in DMSO 2200214-93-1