ChemicalBook >> CAS DataBase List >>SHP099 (hydrochloride)
SHP099 (hydrochloride)
- CAS No.
- 2200214-93-1
- Chemical Name:
- SHP099 (hydrochloride)
- Synonyms
- SHP-099,SHP 099,SHP099 hydrochloride,Inhibitor,Phosphatase,inhibit,SHP-099 hydrochloride,SHP099
- CBNumber:
- CB19043898
- Molecular Formula:
- C16H20Cl3N5
- Molecular Weight:
- 388.72
- MDL Number:
- MFCD30343849
- MOL File:
- 2200214-93-1.mol
Last updated:2024-07-02 08:55:01
SHP099 (hydrochloride) Chemical Properties,Uses,Production
Description
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). Because it is an oncoprotein associated with multiple cancer-related diseases, as well as a potential immunomodulator, controlling SHP2 activity is of significant therapeutic interest.
target
SHP2 inhibitor with IC50 =0.07 μM.
SHP099 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
SHP099 (hydrochloride) Suppliers
Global( 12)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9949 | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1990 | 58 |
Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 9999 | 58 |
Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. | 17771424646 | shoubull@126.com | China | 966 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
2200214-93-1(SHP099 (hydrochloride))Related Search:
SHP-099,SHP 099,SHP099 hydrochloride,Inhibitor,Phosphatase,inhibit,SHP-099 hydrochloride,SHP099
2200214-93-1