ChemicalBook >> CAS DataBase List >>N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride structure

CAS No.: 2309756-20-3

Chemical Name:: N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride

Synonyms: YW3 56 (hydrochloride) (technical grade),YW356 (hydrochloride) (technical grade),YW-3-56 (hydrochloride) (technical grade);N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride

CBNumber:: CB19043924

Molecular Formula:: C27H33Cl2N5O2

Molecular Weight:: 530.49

MDL Number:

MOL File:: 2309756-20-3.mol

Last updated:2023-05-21 10:59:17

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N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Properties

storage temp.	Store at -20°C
solubility	Methanol: 10 mg/ml

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17731	YW3-56 (hydrochloride) (technical grade) ≥80%	2309756-20-3	500μg	$107	2022-04-27	Buy
Cayman Chemical	17731	YW3-56 (hydrochloride) (technical grade) ≥80%	2309756-20-3	1mg	$204	2022-04-27	Buy
Cayman Chemical	17731	YW3-56(hydrochloride)(technicalgrade) ≥80%	2309756-20-3	5mg	$697	2022-04-27	Buy

Product number	Packaging	Price	Buy
17731	500μg	$107	Buy
17731	1mg	$204	Buy
17731	5mg	$697	Buy

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Chemical Properties,Uses,Production

Biological Activity

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1 It inhibits the growth of U2OS osteosarcoma cells (IC50 = ~2.5 μM) in a p53-dependent manner via induction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2

References

1.Wang, Y., Li, P., Wang, S., et al.Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activityThe Journal of Biological Chemisty287(31)25941-25952(2012) 2.Wang, S., Chen, X.A., Hu, J., et al.ATF4 gene network mediates cellular response to the anticancer PAD inhibitor YW3-56 in triple-negative breast cancer cellsMol. Cancer Ther.14(4)877-888(2015)

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19703	58

Supplier	Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
TargetMol Chemicals Inc.	58

N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide,monohydrochloride YW3 56 (hydrochloride) (technical grade),YW356 (hydrochloride) (technical grade),YW-3-56 (hydrochloride) (technical grade) 2309756-20-3